Unmasking Mycosis Fungoides/Sézary Syndrome from preceding or co-existing benign inflammatory dermatoses requiring systemic therapies: Patients frequently present with advanced disease and have an aggressive clinical course.

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Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research

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Publication date: Available online 11 December 2019Source: Journal of ColoproctologyAuthor(s): José Antonio Dias da Cunha e Silva, Laís Lima, Lygia De George, Thalita Araújo Sant’Ana, Marcus ValadãoAbstractThe Buschke-Lowenstein tumor, known as the giant condyloma acuminatum, is a rare lesion of the anorectal and PerianaL region; it is sexually transmitted and associated with human papilloma virus, types 6 and 11. Histologically, it is a benign tumor, but it can reach big proportions and may behave aggressively. The purpose of this study is to report the case of a patient diagnosed with HI...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
Condition:   Acute Lymphoblastic Leukemia ,Lymphomas Intervention:   Biological: Anti-CD19 CAR-T Sponsor:   The First Affiliated Hospital of Nanchang University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Acute Leukemia;   Acute Lymphoblastic Leukemia;   Acute Myeloid Leukemia;   Adult Diffuse Large Cell Lymphoma;   Anaplastic Large Cell Lymphoma;   Burkitt Lymphoma;   Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Chronic Myelomonocytic Leukemia;   Hodgkin Lymphom a;   Lymphoblastic Lymphoma;   Lymphoplasmacytic Lymphoma;   Mantle Cell Lymphoma;   Mixed Phenotype Acute Leukemia;   Myelodysplastic Sy...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Recurrent Ependymoma;   Recurrent Ewing Sarcoma;   Recurrent Hepatoblastoma;   Recurrent Langerhans Cell Histiocytosis;   Recurrent Malignant Germ Cell Tumor;   Recurrent Malignant Glioma;   Recurrent Malignant Solid Neoplasm;   Recurrent Medulloblastoma;   Recurrent Ne uroblastoma;   Recurrent Non-Hodgkin Lymphoma;   Recurrent Osteosarcoma;   Recurrent Peripheral Primitive Neuroectodermal Tumor;   Recurrent Rhabdoid Tumor;   R...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: December 2019Source: Cytotherapy, Volume 21, Issue 12Author(s): Seshu Tyagarajan, David Schmitt, Christopher Acker, Erik RutjensAbstractTisagenlecleucel, a CD19-specific autologous chimeric antigen receptor (CAR)–T cell therapy, is efficacious for the treatment of relapsed/refractory B-cell precursor acute lymphoblastic leukemia and diffuse large B-cell lymphoma. The tisagenlecleucel manufacturing process was initially developed in an academic setting and subsequently transferred to industry for qualification, validation and scaling up for global clinical trials and commercial distribution. Use of f...
Source: Cytotherapy - Category: Cytology Source Type: research
Authors: Puderecki M, Wronecki L, Cięszczyk K, Szumiło J Abstract Organic basis of gastrointestinal symptoms is in the scope of many specialists. In this article lymphocytic gastritis, relatively newly described and not widely-known entity is presented. The lesion is characterized by presence of numerous mature lymphocytes in the surface and foveolar epithelium, as well as lymphocytic infiltration of the lamina propria. According to the definition at least 25 lymphocytes per 100 gastric epithelial cells is now required for the diagnosis. Literature found in wide r...
Source: Polish Journal of Pathology - Category: Pathology Tags: Pol J Pathol Source Type: research
THURSDAY, Dec. 12, 2019 -- Among children with Hodgkin lymphoma (HL) enrolled in phase III trials, nonwhite patients have an increased risk for death, according to a study published in the Nov. 10 issue of the Journal of Clinical Oncology. Justine...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Publication date: Available online 11 December 2019Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Giusy Elia, Silvia Martina Ferrari, Maria Rosaria Galdiero, Francesca Ragusa, Sabrina Rosaria Paparo, Ilaria Ruffilli, Gilda Varricchi, Poupak Fallahi, Alessandro AntonelliAbstractAnticancer immunotherapy, in the form of immune checkpoint inhibition (ICI), is a paradigm shift that has transformed the care of patients with different types of solid and hematologic cancers. The most notable improvements have been seen in patients with melanoma, non-small-cell lung, bladder, renal, cervical, u...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
We present a case of a 58-year-old man who presented with 5 years of cutaneous symptoms and several months of fevers and night sweats, ultimately diagnosed as MF. Owing to diffuse CD30 positivity, he was a candidate for brentuximab vedotin, an antibody-drug conjugate medication that selectively targets the CD30 antigen. This resulted in an excellent therapeutic response.
Source: Journal of General Internal Medicine - Category: Internal Medicine Source Type: research
Conclusions Epidemiological studies have repeatedly helped identify definitive triggers for several diseases. As highlighted in this perspective report, previous studies strongly argue for the interplay between intrinsic factors and putative preventable extrinsic triggers/promoters for CTCL. Given the evidence of geographical regional clustering of CTCL patients, CTCL occurrence in unrelated family members and recent evidence implicating S. aureus in the pathogenesis/progression of CTCL, more research is needed to decipher the precise mechanism by which specific environmental exposures may be driving the pathogenesis of t...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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