Role of the cytoplasmic isoform of RBFOX1/A2BP1 in establishing the architecture of the developing cerebral cortex

Conclusions: Impaired Rbfox1-iso2 function was found to cause abnormal corticogenesis during brain development. The abnormal process may underlie the basic pathophysiology of ASD and other neurodevelopmental disorders and may contribute to the emergence of the clinical symptoms of the patients with RBFOX1 gene abnormalities.

http://www.molecularautism.com/content/6/1/56

Source: BioMed Central - October 20, 2015 Category: Journals (General) Authors: Nanako HamadaHidenori ItoIkuko IwamotoRika MorishitaHidenori TabataKoh-ichi Nagata Source Type: research