Limited Access to Pyrimethamine Prompts Update of Toxoplasmosis Section of the Adult and Adolescent OI Guidelines

The Toxoplasma gondii Encephalitis section of the Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents has been updated to provide clinicians with guidance on the use of trimethoprim-sulfamethoxazole for treatment of acute infection and chronic maintenance therapy for suspected or documented toxoplasmosis if pyrimethamine is not readily available.   On September 10, 2015, the OI Guidelines author panel issued this Notice of Availability of Pyrimethamine, which is guidance on what to do if pyrimethamine is unavailable to treat or prevent Toxoplasma encephalitis, Pneumocystis pneumonia, and Isospora infection.