'Reversible' tumor suppressor loss: Key to new brain cancer therapies?

(University of Texas M. D. Anderson Cancer Center) It's no surprise that people enjoy warm places like Hawaii but may suffer in hostile locales such as Antarctica. A tumor suppressor gene called PTEN is similar in that it is affected by the microenvironments of certain bodily organs to which it travels.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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AbstractPurpose of reviewAs cancer survivor rates improve with early screening and modern treatment options, cardiotoxicity is becoming an increasing problem. It is imperative for physicians to recognize adverse events early so that appropriate measures can be taken before advanced and permanent cardiac dysfunction ensues. In this review, we will evaluate the literature surrounding current cardiac biomarkers in the detection of cardiotoxicity during cancer treatment as well as discuss the role of emerging novel biomarkers.Recent findingsTroponin and brain natriuretic peptides show promise in the detection of subclinical ca...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
Authors: Yamamoto Y, Sasaki N, Kumagai K, Takeuchi S, Toyooka T, Otani N, Wada K, Narita Y, Ichimura K, Namba H, Mori K, Tomiyama A Abstract Glioblastoma (GBM) still carries a poor prognosis due to the refractoriness against antitumor drugs. Temozolomide (TMZ), one of the few standard therapy drugs against GBM worldwide, has only limited effect due to acquired TMZ resistance of GBM. Therefore, development of novel therapeutic methods to overcome the TMZ resistance of GBM is urgent. The brain is the most cholesterol-rich organ in the human body, so modulation of cholesterol in tumor cells originating from the brain ...
Source: Neurologia Medico-Chirurgica - Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research
This issue of Neurologic Clinics is devoted to nervous system tumors as well as neurologic complications of cancer and cancer therapy. Since the last issue devoted to neuro-oncology 10 years ago, increased understanding of the molecular underpinnings of primary brain tumors has led to the addition of molecular parameters for the first time to the WHO classification of central nervous system tumors. Therefore, the first half of this issue focuses on the molecular pathogenesis of gliomas, the reasoning behind the recent changes in WHO classification, and their implications for management of adult and pediatric brain tumors.
Source: Neurologic Clinics - Category: Neurology Authors: Tags: Preface Source Type: research
Abstract Subsequent malignant neoplasms (SMNs) in childhood cancer survivors cause substantial morbidity and mortality. This review summarizes recent literature on SMN epidemiology, risk factors, surveillance, and interventions. Survivors of childhood cancer experience long-term increased SMN risk compared with the general population, with a greater than twofold increased solid tumor risk extending beyond age 40 years. There is a dose-dependent increased risk for solid tumors after radiotherapy, with the highest risks for tumors occurring in or near the treatment field (eg, greater than fivefold increased risk for...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Oncol Source Type: research
This study indicates that frailty and other age-related diseases could be prevented and significantly reduced in older adults. Getting our heart risk factors under control could lead to much healthier old ages. Unfortunately, the current obesity epidemic is moving the older population in the wrong direction, however our study underlines how even small reductions in risk are worthwhile." The study analysed data from more than 421,000 people aged 60-69 in both GP medical records and in the UK Biobank research study. Participants were followed up over ten years. The researchers analysed six factors that could impa...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
AbstractPurpose of ReviewIn this article, we review current and emerging approaches to biomarker discovery to facilitate early diagnosis of cancer therapy-associated cardiovascular toxicity.Recent FindingsAlthough small studies have demonstrated an association between established biomarkers of cardiac injury (troponins and brain natriuretic peptide) and acute or subacute cardiotoxicity, there is insufficient evidence to support their use in routine clinical care. Preclinical studies to define the molecular mechanisms of cardiotoxicity, as well as the use of unbiased “omics” techniques in small patient cohorts, ...
Source: Current Cardiology Reports - Category: Cardiology Source Type: research
Conclusion: The 18F-Ala-BF3 was successfully synthesized through one-step 18F-19F isotope exchange with fine specific activity and good radiochemical yield. Following in vitro bio-distribution and in vivo PET imaging in gastric tumor xenografts bearing mice and healthy mice revealed high tumor to normal tissue rate consist with fine tumor imaging of 18F-Ala-BF3. This study shed light on ASCT2 as a cancer biomarker for clinical diagnosis, and emphasized the usefulness of BAAs in tumor PET imaging. 18F-Ala-BF3 represents a useful molecular platform for tumor diagnosis.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Radiolabeled Small Molecules and New Applications - Oncology Source Type: research
(Mayo Clinic) Mayo Clinic researchers have discovered that a molecular communication pathway -- thought to be defective in cancer -- is a key player in determining the effectiveness of measles virus oncolytic cancer treatment in ovarian and aggressive brain cancers. This discovery enabled researchers to develop an algorithm to predict treatment effectiveness in individual patients. The findings appear in the Journal of the National Cancer Institute.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Authors: Wang R, Zhou T, Liu W, Zuo L Abstract Cancer cells subjected to ionizing radiation may release signals which can influence nearby non-irradiated cells, termed bystander effects. The transmission of bystander effects among cancer cells involves the activation of inflammatory cytokines, death ligands, and reactive oxygen/nitrogen species. In addition to bystander effects, two other forms of non-target effects (NTEs) have been identified in radiotherapy, as one is called cohort effects and the other is called abscopal effects. Cohort effects represent the phenomenon where irradiated cells can produce signals ...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
"Effect of polygodial and its direct derivatives on the mammalian Na+/K+-ATPase activity". Eur J Pharmacol. 2018 Apr 28;: Authors: Garcia DG, Gonçalves-de-Albuquerque CF, da Silva CI, Kiss R, Dasari R, Chandra S, Kornienko A, Burth P Abstract The sesquiterpene polygodial is an agonist of the transient receptor potential vanilloid 1 (TRPV1). Our group recently reported the synthesis and anticancer effects of polygodial and its derivatives, and showed that these compounds retain activity against apoptosis- and multidrug-resistant cancer cells. Herein, we tested the inhibitory effect of ...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharmacol Source Type: research
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