Dining in: intracellular bacterial pathogen interplay with autophagy.

Dining in: intracellular bacterial pathogen interplay with autophagy.
Curr Opin Microbiol. 2015 Oct 10;29:9-14
Authors: Winchell CG, Steele S, Kawula T, Voth DE
Abstract
Intracellular bacterial pathogens have evolved many ways to manipulate host cells for successful infection. Many of these pathogens use specialized secretion systems to inject bacterial proteins into the host cytosol that manipulate cellular processes to favor infection. Autophagy is a eukaryotic cellular remodeling process with a critical role in many diseases, including bacterial clearance. A growing field of research highlights mechanisms used by intracellular bacteria to manipulate autophagy as a pro-survival strategy. This review focuses on a select group of bacterial pathogens with diverse intracellular lifestyles that exploit autophagy-derived nutrients and membrane for survival. This group of pathogens uses secretion systems and specific effectors to subvert distinct components of autophagy. By understanding how intracellular pathogens manipulate autophagy, we gain insight not only into bacterial pathogenesis but also host cell signaling and autophagolysosome maturation.
PMID: 26462048 [PubMed - as supplied by publisher]

Source: Current Opinion in Microbiology - October 10, 2015 Category: Microbiology Authors: Winchell CG, Steele S, Kawula T, Voth DE Tags: Curr Opin Microbiol Source Type: research