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Greeks Gone West: The Geneticist Helping To Treat 'Gigantism'

Constantine A. Stratakis - Greeks Gone West by HuffPost_Greece In the third episode of HuffPost Greece's video series 'Greeks Gone West,' we introduce Constantine A. Stratakis, M.D. D.Sc., a tenured investigator in the NICHD, who has been the head of the Section on Genetics and Endocrinology (SEGEN) since its inception in 1999. His work is focused on treating the rare condition of 'gigantism.' The research began with a family who came to the the U.S. National Institutes of Health for treatment for gigantism in the mid-1990s. In that family, the mother and two of her sons all had the condition. This is his story. Watch the first and second episodes of 'Greeks Gone West' here and here. -- This feed and its contents are the property of The Huffington Post, and use is subject to our terms. It may be used for personal consumption, but may not be distributed on a website.
Source: Science - The Huffington Post - Category: Science Source Type: news

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Endocrine Practice, Ahead of Print.
Source: Endocrine Practice - Category: Endocrinology Authors: Source Type: research
Endocrine Practice, Ahead of Print.
Source: Endocrine Practice - Category: Endocrinology Authors: Source Type: research
We aimed to determine the long-term effects of Gamma knife radiosurgery (GKS) on remnants in the cavernous sinus (CS) after transsphenoidal surgery (TSS) for acromegaly and to identify its possible adverse effects.
Source: World Neurosurgery - Category: Neurosurgery Authors: Tags: Original article Source Type: research
Funding Opportunity PA-18-052 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) encourages R21 applications that propose to conduct secondary analyses of existing data sets relevant to diabetes and selected endocrine and metabolic diseases including thyroid, parathyroid and Cushings diseases and acromegaly; and genetic metabolic disease including cystic fibrosis, lysosomal storage diseases, and disorders of the urea cycle, amino acid metabolism and metal transport where the focus is on peripheral metabolism or organ function; obesity, liver diseases, alimentary GI tract diseases and ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Conclusion: Reduction in growth hormone levels and insulin-like growth factor type 1 can decrease the LVM and LVMI, which directly or indirectly contributes to the improvement in diastolic as well as systolic function and probably mortality.
Source: Neurology India - Category: Neurology Authors: Source Type: research
Subhash Yadav, Eesh BhatiaNeurology India 2017 65(6):1223-1224
Source: Neurology India - Category: Neurology Authors: Source Type: research
Antonio Ribeiro-Oliveira, Márta Korbonits, Claudia M V FreireNeurology India 2017 65(6):1225-1226
Source: Neurology India - Category: Neurology Authors: Source Type: research
ConclusionsThe results from these long-term placebo-controlled studies confirm the established safety profile of long-acting OCT, in particular low risk of cardiac, hepatic and renal toxicity in a high-risk population.
Source: Endocrine - Category: Endocrinology Source Type: research
Conclusion Regarding operated cases of GH-producing pituitary adenoma, acromegaly clinical manifestations tended to be milder at diagnosis in later years of the decade, and acromegaly was diagnosed at lower IGF-1 levels and in smaller lesions. Further study is mandatory for the generalization of this trend.
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
AbstractPurposeThere is a paucity of epidemiological information on treatment and imaging of pituitary adenomas in Australia.MethodsAustralian data on pituitary surgery, hospital admissions for pituitary adenomas, and pituitary imaging on patients 15 years and over were obtained from administrative databases between 2000/2001 and 2014/2015. Changes over time and by age and sex were assessed.ResultsIn 2014/15 there were 37.7 pituitary procedures/million population, corresponding to a 35.4% (p 
Source: Endocrine - Category: Endocrinology Source Type: research
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