Expression of cleaved SNAP‐25 after bladder wall injection of onabotulinumtoxinA or abobotulinumtoxinA: A comparative study in the mice

ConclusionsThese findings confirm that, when injected in the bladder wall, in the same unit amount and same volume, onabotA is 1.6 times more potent to cleave SNAP‐25 than abobotA. The conversion ratio suggested by these experiments is 1:1.6 between onabotA and abobotA. Each injection, although preformed in the same way, may induce substantially different amounts of cSNAP‐25. Neurourol. Urodynam. © 2015 Wiley Periodicals, Inc.
Source: Neurourology and Urodynamics - Category: Urology & Nephrology Authors: Tags: Original Basic Science Article Source Type: research