How smoking REALLY affects the body, from stomach ulcers and acne to infertility
Smokers are twice as likely to be infertile and more likely to develop ulcers and bowel disorders such as Crohn's, according to an interactive tool by online clinic HealthExpress.co.uk.
We report a case of acute myeloid leukemia with myelodysplasia-related changes in a patient with Crohn ’s disease. The patient was diagnosed with Crohn’s disease at the age of 47 years and was treated with the tumor necrosis factor α inhibitors adalimumab and infliximab, and a short course of azathioprine. Four years later, the patient developed acute myeloid leukemia with myelodysplasia that in volved mainly erythropoiesis. Crohn’s disease is associated with an increased risk of cancers including hematological malignancies. Cancer surveillance including hematology assessment is warranted to monitor...
Rosy cheeks can be the result of many benign causes, such as being hot. However, there are several causes that may require medical attention, including acne, rosacea, and lupus. We look at some of the causes of facial flushing and explain the steps that people can take to treat, manage, and prevent them.
Condition: Crohn's Disease Interventions: Drug: Placebo; Drug: TD-1473 Sponsor: Theravance Biopharma R & D, Inc. Not yet recruiting
Updated Date: Aug 17, 2018 EST
This study aimed to evaluated the anti-inflammatory activity of KM1608, which is composed of three natural herbs in a mouse model of dextran sodium sulfate (DSS)-induced ulcerative colitis. The anti-inflammatory activity and underlying mechanism were assessed in vitro using LPS-treated RAW264.7 cells. The in vivo effect of KM1608 on DSS-induced colitis was examined after oral administration in mice. KM1608 significantly inhibited the inflammatory mediators such as nitric oxide, interleukin (IL)-6, monocyte chemotactic protein 1 (MCP-1) and tumor necrosis factor (TNF)-α in LPS-treated RAW264.7 cells. The inhibitor...
As SCs play a central role in germ cesurvival, their death may results in marked germ cell loss and infertility (Eid et al., 2012; Oliveira et al., 2015). As SCs play a central role in germ cell survival, their death may result in marked germ cell loss and infertility (Eid et al., 2012; Oliveira et al., 2015). As SCs play a central role in germ cell survival, their death may result in marked germ cell loss and infertility (Eid et al., 2012; Oliveira et al., 2015). Sertoli cells (SCs) are the only somatic cells within the seminiferous tubules and are essential for regulating spermatogenesis.
NLRP3 is part of the NLRP3 inflammasome and a global sensor of cellular damage. It was recently discovered in rodent Sertoli cells. We investigated NLRP3 in mouse, human and non-human primate (marmoset and rhesus macaque) testes, employing immunohistochemistry. Sertoli cells of all species expressed NLRP3, and the expression preceded puberty. In addition, peritubular cells of the adult human testes expressed NLRP3. NLRP3 and associated genes (PYCARD, CASP1, IL1B) were also found in isolated human testicular peritubular cells and the mouse Sertoli cell line TM4. Male infertility due to impairments of spermatogenesis may be ...
In conclusion, in this study, we demonstrated for the first time a novel target for FXR and that the activated receptor alters the acquisition of sperm fertilising ability. We showed that sperm itself express the FXR and it is responsive to specific ligands of the receptor; therefore, bile acids influence this cell both in male and in female genital tracts. It might be hypothesized that bile acid levels could be involved in infertility with idiopathic origin as these compounds are not systematically measured in men undergoing medically assisted procreation.
ConclusionsAgreement among five pediatric radiologists was moderate to substantial for SAR-AGA standardized impressions and fair to moderate for key imaging findings of pediatric and young adult CD.