Mouse model of proximal colon-specific tumorigenesis driven by microsatellite instability-induced Cre -mediated inactivation of Apc and activation of Kras
Conclusions
These results demonstrated the validity of the G22Cre;Apc
flox/flox
;Kras
G12D
mice as a new mouse model with oncogenic Kras activation. We believe that this model can facilitate efforts to define novel factors that contribute to the pathogenesis of human colorectal cancer with KRAS mutations.
Source: Journal of Gastroenterology - Category: Gastroenterology Source Type: research
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