Gabapentin can significantly improve dystonia severity and quality of life in children.

Gabapentin can significantly improve dystonia severity and quality of life in children. Eur J Paediatr Neurol. 2015 Sep 28; Authors: Liow NY, Gimeno H, Lumsden DE, Marianczak J, Kaminska M, Tomlin S, Lin JS Abstract INTRODUCTION: Gabapentin has been used in the management of neuropathic pain, epilepsy and occasionally movement disorders. METHODS: A four-year retrospective, observational study analysed the use of gabapentin for severe dystonia in children at the Evelina London Children's Hospital. Motor severity was classified according to the Gross Motor Function Classification System (GMFCS), Dystonia Severity Assessment Plan (DSAP) and levels of impairment in activities of daily living were graded according to the WHO International Classification of Functioning, Disability and Health, Children &Youth version (ICF-CY) before and after gabapentin. RESULTS: The majority of the 69 children reported were level 5 GMFCS (non-ambulant). The DSAP grade fell significantly from grade 3 before to grade 1 after gabapentin. Significant improvements in median ICF-CY grades were seen following gabapentin in sleep quality, sleep amount, mood &agreeableness, pain, general muscle tone, involuntary muscle contractions and seating tolerance (p 
Source: European Journal of Paediatric Neurology - Category: Neurology Authors: Tags: Eur J Paediatr Neurol Source Type: research

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