Antibiotic surgical prophylaxis increases nasal carriage of antibiotic resistant staphylococci.

Antibiotic surgical prophylaxis increases nasal carriage of antibiotic resistant staphylococci. J Med Microbiol. 2015 Oct 6; Authors: McMurray CL, Hardy KJ, Verlander NQ, Hawkey PM Abstract Staphylococci are a significant cause of hospital acquired infection. Nasal carriage of S. aureus is an important risk factor for infection in surgical patients, and coagulase negative staphylococci (CNS) are a major cause of prosthetic joint infections. The impact that antibiotic surgical prophylaxis has on the nasal carriage of staphylococci has not been studied. Daily nasal swabs were taken from 63 patients who received antibiotic surgical prophylaxis, and 16 patients who received no antibiotics. Total aerobic bacterial count (TBC), Staphylococcus aureus and coagulase negative staphylococci (CNS) were enumerated by culture from nasal swabs. Representative isolates were typed by SIRU VNTR and PFGE, and MIC to nine antibiotics was determined. After antibiotic administration, there was a reduction in S. aureus counts (median - 2.3 log10cfu/m) in 64.0% S. aureus carriers, compared with only a 0.89log10cfu/ml reduction in 75.0% of S. aureus carriers who did not receive antibiotics. A greater increase in the nasal carriage rate of methicillin resistance (MR) CNS was observed after antibiotic surgical prophylaxis compared with hospitalisation alone, with increases of 16.4% and 4.6% respectively. Antibiotic resistant S. epidermidis carriage rate increa...
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research