Fertility treatments are getting better – and more realistic | Rebecca Schiller

Developments such as ovarian tissue transplants and single embryo transfer are making motherhood a graspable reality, but services must be safe and accessibleI have been lucky. My children were created and were born with relative ease. Speaking to those who I know have struggled with infertility gives some small insight into the complex series of physical, emotional, financial and medical transactions that operate on a intensely heightened plane of reality.For the one in six couples in the UK who struggle to conceive, the news of successful ovarian tissue transplants leading to pregnancy could bring new hope. A Danish study followed women who underwent the procedure after cancer treatment had reduced their fertility. The transplanting of frozen tissue was found to be safe and a third of women went on to become pregnant – half without the need for IVF. The procedure offers tangible results, not just for cancer patients but also for women who want to postpone motherhood until later in life. Equally heartening is the news that womb transplants are soon to take place in the UK as part of a clinical trial. Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Fertility problems Health Society IVF Medical research Science Ovarian cancer Childbirth & wellbeing Life and style Reproduction UK news Denmark Source Type: news

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Although cancer remains a critical health concern, significant medical advances in cancer detection and treatment have improved survival rates for patients. In children receiving total body radiation (TBI), bone-marrow transplant (BMT), or cyclophosphamide equivalent dose (CED) of>4,000mg/m2, the risk of infertility is significant. The National Physicians Cooperative (NPC) has published site-specific articles compiling data regarding use of cryopreserved tissue, return of endocrine function, and pregnancy outcomes, however no comprehensive review has been conducted.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
A second woman in the U.S. born without a uterus has given birth to a baby, thanks to a uterus transplant. The birth took place at Baylor University Medical Center at Dallas, a part of Baylor Scott &White, which performed the first birth via uterus transplant late last year. The baby, born in February, is a girl. The hospital is not revealing the identity of the mother, but says the pregnancy and birth were uncomplicated. The birth is the second in the hospital’s ongoing uterus transplant clinical trial. The women in the trial have absolute uterine factor infertility (AUI), which means their uterus is nonfunction...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized fertility healthytime onetime Source Type: news
This study shows that lifespan-extending conditions can slow molecular changes associated with an epigenetic clock in mice livers. Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging "clock", a robust biomarker of aging. However, while genetic, dietary and drug interventions can extend lifespan, their impact on the epigenome is uncharacterised. To fill this knowledge gap, we defined...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study was in part funded from the Deutsche Forschungsgemeinschaft (# DI 1525) and the Wilhelm Sander Foundation (2012.127.1) and did not receive any funding from a commercial company. No competing interests. TRIAL REGISTRATION NUMBER None.
Source: Human Reproduction - Category: Reproduction Medicine Authors: Tags: Infertility Source Type: research
STUDY QUESTION What are the results of transplanting cryopreserved ovarian tissue? SUMMARY ANSWER The transplanted ovarian tissue can last up to 10 years, with no relapses following the 53 transplantations, and the chance of a successful pregnancy is currently around one in three for those with a pregnancy-wish. WHAT IS KNOWN ALREADY Cryopreservation of ovarian tissue is now gaining ground as a valid method for fertility preservation. More than 36 children worldwide have now been born following this procedure. STUDY DESIGN, SIZE, DURATION This is a retrospective cohort study of 41 women who had thawed ovarian tissue tra...
Source: Human Reproduction - Category: Reproduction Medicine Authors: Tags: Infertility Source Type: research
In this study, infertility in mice was caused by CTx, and the ability of FGSCs to restore ovarian function or even produce offspring was assessed. We had successfully isolated and purified the FGSCs from adult female mice two weeks after CTx. After infection with GFP-carrying virus, the FGSCs were transplanted into ovaries of mice with infertility caused by CTx. Finally, ovarian function was restored and the recipients produced offspring long-term. These findings showed that mice with CTx possessed FGSCs, restoring ovarian function and avoiding immune rejection from exogenous germline stem cells.
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
Recent research shows improvement in long-term survival rates for childhood cancer patients, but also highlights the challenges that remain for many of the almost 400,000 survivors in the United States.  Among these survivors are women facing gynecological health issues from the late effects of their treatment. What follows are several areas of concern that gynecologists and obstetricians should consider when treating women who had cancer as girls. 1. Treatment summary. An adult woman who had cancer during childhood should have a written summary of treatments she received. Certain commonly utilized treatments for chil...
Source: Kevin, M.D. - Medical Weblog - Category: Journals (General) Authors: Tags: Conditions Cancer Source Type: blogs
CHICAGO (AP) -- Barely 2 years old, Talia Pisano is getting tough treatment for kidney cancer that spread to her brain. She's also getting a chance at having babies of her own someday.  To battle infertility sometimes caused by cancer treatment, some children's hospitals are trying a futuristic approach: removing and freezing immature ovary and testes tissue, with hopes of being able to put it back when patients reach adulthood and want to start families. No one knows yet if it will work. It has in adults - more than 30 babies have been born to women who had ovarian tissue removed in adulthood, frozen, and put back af...
Source: Science - The Huffington Post - Category: Science Source Type: news
The UK papers today welcome news of a world first in fertility treatment. As The Guardian concisely summarises: "A young woman in Belgium has become the first to give birth to a healthy baby after having her fertility restored by a transplant of ovarian tissue that was removed and frozen when she was a child". The woman was born with sickle cell anaemia, a serious inherited blood disorder where the red blood cells, which carry oxygen around the body, develop abnormally. This can cause severe pain and organ damage. Due to the severity of her condition, a decision was taken to perform a stem cell transplant. This ...
Source: NHS News Feed - Category: Consumer Health News Tags: Medical practice Pregnancy/child QA articles Source Type: news
Conclusion: there is no increased risk of doing the lymph node dissection early on.   Dr. Eggener-CON   Basics Lymph node dissections rarely done, even for large tumors, because there is no proven therapeutic or staging benefit for low risk patients.  A Mayo study revealed no data showing therapeutic benefit in high risk patients.  For clinically node negative high risk patients, there is staging value but no proven therapeutic benefit. Rate of positive nodes is associated with stage and grade; the higher the stage and grade, the more likely there will be positive nod...
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news
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