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FDA Updates Atazanavir Oral Powder Label

"On September 24, 2015, FDA approved revisions to the Reyataz (atazanavir) oral powder label to include dosing recommendations for patients three months and older weighing at least 5 kg. This represents the addition of a new pediatric weight band. Previously the oral powder formulation was for patients three months and older weighing at least 10 kg.   "Reyataz oral powder must be taken with ritonavir and is not recommended for use in children who weigh less than 5 kg."   The updated labeling will be available at the FDA website.   More information is available: FDA: Press release AIDSinfo: Patient fact sheet on atazanavir

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CONCLUSIONS: Our study suggests that adherence to ART in Latin America and Caribbean may be below the sufficient levels required for a successful long-term viral load suppression. PMID: 29356390 [PubMed - in process]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
CONCLUSIONS: Differentiated care for mothers and infants represents an opportunity to provide client-centred care that reduces the burden on clients and health systems while improving the quality and uptake of services for families. However, with decreasing funding, stable HIV incidence, and aspirations for sustainability, it is critical to consider efficient, customized and cost-effective models of care for these populations as we aspire to eliminate mother-to-child transmission of HIV. PMID: 29356376 [PubMed - in process]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
CONCLUSIONS: TRIP's recruiting techniques, including prioritizing networks of the recently infected, find undiagnosed HIV-positive people efficiently. They should be integrated with standard practice to improve case-finding. Research should test these techniques in other socio-epidemiologic contexts. CLINICAL TRIAL REGISTRY: Registered ClinicalTrials.gov: NCT01827228. PMID: 29356365 [PubMed - in process]
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
We report a case of a 31-year-old woman who presented with renal colic. Various hematological, biochemical and radiological investigations were performed and a slightly enlarged right parathyroid was found. A clinical diagnosis of parathyroid adenoma was made and a right parathyroidectomy was done. Intraoperatively the surgeon had no suspicion of malignancy but microscopically the lesion was malignant and a final diagnosis of parathyroid carcinoma was rendered based on the criteria of invasion. Since there is no gold standard, a multidisciplinary approach, including the entire clinical, biochemical, radiological and pathol...
Source: GMS German Medical Science - Category: General Medicine Tags: Ger Med Sci Source Type: research
Cycling can improve health and well-being by reducing inactivity. Concern about collision crashes may be a barrier to participation since collision crashes can lead to significant mortality and morbidity. The conspicuity of cyclists may be a contributory f...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news
In January, 2018, Academic Press published my bookPrecision Medicine and the Reinvention of Human Disease. This book has an excellent " look inside " at itsGoogle book site, which includes the Table of Contents. In addition, I thought it might be helpful to see the topics listed in the Book's index. Note that page numbers followed by f indicate figures, t indicate tables, and ge indicate glossary terms.AAbandonware, 270, 310geAb initio, 34, 48ge, 108geABL (abelson leukemia) gene, 28, 58ge, 95 –97Absidia corymbifera, 218Acanthameoba, 213Acanthosis nigricans, 144geAchondroplasia, 74, 143ge, 354geAcne, 54ge, 1...
Source: Specified Life - Category: Information Technology Tags: index jules berman jules j berman precision medicine Source Type: blogs
[263Chat] National AIDS Council last week received 12 new HUMASTAR 200 chemistry analyzers worth 240 000 euros from Diagnostic Laboratory Suppliers- in a major boost to the country's health ministry.
Source: AllAfrica News: Health and Medicine - Category: African Health Source Type: news
[Daily Trust] Bauchi -The Bauchi State Agency for the control of HIV/AIDS, Tuberculosis/Leprosy and Malaria, (BACATMA) has disclosed that it has provided treatment, care and support to 16,000 HIV positive patients in the state from 2015 to 2017.
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
The recently approved combination of dolutegravir and rilpivirine is effective for maintaining virological suppression in adults with HIV-1, according to results from the SWORD-1 and SWORD-2 noninferiority studies.Reuters Health Information
Source: Medscape Hiv-Aids Headlines - Category: Infectious Diseases Tags: HIV/AIDS News Source Type: news
AbstractPurpose of ReviewNeurocognitive disorders are not uncommon in HIV-positive patients but their pathogenesis is multifactorial and incompletely understood. After excluding contributing comorbidities, several factors may impair neurocognition including severe immune suppression, incomplete antiviral efficacy, drugs' persistent immune activation, vascular abnormalities, and drugs' neurotoxicity. The effectiveness of targeted antiretroviral strategies on these risk factors is unknown.Recent FindingsRecent studies support the idea that residual cerebrospinal fluid HIV RNA in the setting of plasma viral suppression is ass...
Source: Current HIV/AIDS Reports - Category: Infectious Diseases Source Type: research
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