Clonal evolution of pre-leukemic hematopoietic stem cells in acute myeloid leukemia

Acute myeloid leukemia (AML) is an aggressive blood cancer that results from an abnormal expansion of uncontrollably proliferating myeloid progenitors that have lost the capacity to differentiate. AML encompasses many genetically distinct sub-types that predominantly develop de novo. However, AML can also arise from pre-malignant myeloid conditions, such as myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPNs) or develop as the result of exposure to genotoxic agents used to treat unrelated malignancies.

Source: Experimental Hematology - October 8, 2015 Category: Hematology Authors: Stephen M. Sykes, Konstantinos D. Kokkaliaris, Michael D. Milsom, Ross L. Levine, Ravindra Majeti Source Type: research