SOX9 regulates ERBB signalling in pancreatic cancer development

Conclusions
By integrating data from patient samples and mouse models, we found that SOX9 regulates the ERBB pathway throughout pancreatic tumourigenesis. Our work opens perspectives for therapy targeting tumourigenic mechanisms.

Source: Gut - October 8, 2015 Category: Gastroenterology Authors: Grimont, A., Pinho, A. V., Cowley, M. J., Augereau, C., Mawson, A., Giry-Laterriere, M., Van den Steen, G., Waddell, N., Pajic, M., Sempoux, C., Wu, J., Grimmond, S. M., Biankin, A. V., Lemaigre, F. P., Rooman, I., Jacquemin, P. Tags: Pancreas and biliary tract, Pancreatic cancer Source Type: research