Weight loss, exercise may boost fertility odds for women with PCOS

(Reuters Health) - Women who suffer from a leading cause of infertility may increase their odds of conception if they exercise and lose weight, a U.S. study suggests.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news

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AbstractStudy objectiveTo compare pregnancy outcomes in PCOS women undergoing transvaginal ovarian injury (TVOI) and laparoscopic ovarian drilling (LOD)Design126 infertile patients with PCOS were included in this prospective cohort studyCanadian task force classification of level of evidenceIIA.SettingUniversity-affiliated fertility center.PatientsSixty-seven infertile patients with the history of failed in vitro maturation underwent follow-up as the TVOI group. Fifty-nine infertile women who underwent LOD acted as controls. All subjects had PCOS with menstrual irregularity and were anovulatory by repetitive serum progeste...
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
Polycystic ovary syndrome (PCOS) is a common cause of anovulatory infertility. Optimal ovulation induction would achieve ovulation and live birth while minimizing the risk of multiple gestations, birth defects, side-effects, and cost. The optimal first-line agent has evolved based on several notable randomized controlled trials with surprising results. First, based on early data on the value of metformin for ovulation in PCOS, Legro et  al. designed a randomized trial (RT) of extended-release metformin, clomiphene citrate (CC), or both to test the hypothesis that metformin would result in a higher live birth rate than...
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
ConclusionNMR-based metabolic profiling may be successfully applied to find diagnostic biomarkers for PCOS and endometriosis and it might be also used to predict oocyte developmental potential and subsequent outcome.
Source: Metabolomics - Category: Biology Source Type: research
CONCLUSION: In addition to pharmacological interventions, long-term standardized individualized management of PCOS patients is needed to achieve fertility and reduce the risk of metabolic related diseases. PMID: 30706800 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Polycystic ovary syndrome (PCOS) is a common endocrine disorder associated with poor reproductive outcomes, including infertility and pregnancy complications, and poor metabolic outcomes, including insulin resistance, type 2 diabetes, and the metabolic syndrome. Prevalence estimates for PCOS range from 7% to 15% of reproductive-age women worldwide, depending on the diagnostic criteria used. Accordingly, PCOS-associated dysglycemia and obesity are a global public health risk. Despite the public health importance of PCOS, notable gaps exist in the literature regarding its pathophysiology, natural history, and optimal management.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Reflections Source Type: research
This study was planned to test whether follicular fluid (FF) levels of patatin-like phospholipase domain containing 3-gene (PNPLA3:adiponutrin), preptin, kisspeptin, and amylin change in polycystic ovarian syndrome (PCOS). A total of 40 infertile volunteers undergoing IVF/ICSI were included in the study. They were divided into two groups as PCOS (n=20) and control group without PCOS (n=20). The controls were recruited from subjects with a poor ovarian response. The PCOS and control participants were matched according to their body mass index (BMI). Each group of participants underwent ovarian stimulation with GnRH antagoni...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research
Authors: Xu XH, Kou LC, Wang HM, Bo CM, Song XC Abstract Polycystic ovary syndrome (PCOS) is a condition in which a woman's levels of the sex hormones (estrogen and progesterone) are out of balance, leading to the growth of ovarian cysts. PCOS can affect the menstrual cycle, fertility, cardiac function and even appearance of women. Therefore, we aimed to explore the genetic polymorphism of the melatonin receptors 1A and 1B in obese patients with PCOS to identify a new theoretical basis for its treatment. Patients presenting with PCOS (n=359) were enrolled and classified into an obese OB‑PCOS group [body mass inde...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
To evaluate whether a combination of letrozole and clomiphene citrate (CC) results in higher ovulation rates than letrozole alone in infertile women with polycystic ovary syndrome (PCOS).
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Original article Source Type: research
Authors: Radwan, Rasha A. / Abuelezz, Nermeen Z. / Abdelraouf, Sahar M. / Bakeer, Engy M. / Rahman, Abdullah A. Abd El
Source: Journal of Medical Biochemistry - Category: Biochemistry Source Type: research
Abstract Polycystic ovary syndrome (PCOS) is a common cause of infertility. Hyperandrogenism is both a major symptom and key diagnostic trait of PCOS; however, the direct impact of this androgen excess on ovarian dynamics is unclear. By combining a DHT-induced PCOS mouse model with an ex vivo follicle culture system, we investigated the impact of hyperandrogenism on ovarian function. Ovaries from PCOS mice exhibited the characteristic polycystic ovary morphology with numerous large cystic follicles and no corpora lutea present. Isolation and individual culture of preantral and antral follicles from PCOS mice resul...
Source: Endocrinology - Category: Endocrinology Authors: Tags: Endocrinology Source Type: research
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