Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies

Abstract Pathological tau aggregation leads to filamentous tau inclusions and characterizes neurodegenerative tauopathies such as Alzheimer’s disease and frontotemporal dementia and parkinsonism linked to chromosome 17. Tau aggregation coincides with clinical symptoms and is thought to mediate neurodegeneration. Transgenic mice overexpressing mutant human P301S tau exhibit many neuropathological features of human tauopathies including behavioral deficits and increased mortality. Here, we show that the di-phenyl-pyrazole anle138b binds to aggregated tau and inhibits tau aggregation in vitro and in vivo. Furthermore, anle138b treatment effectively ameliorates disease symptoms, increases survival time and improves cognition of tau transgenic PS19 mice. In addition, we found decreased synapse and neuron loss accompanied by a decreased gliosis in the hippocampus. Our results suggest that reducing tau aggregates with anle138b may represent an effective and promising approach for the treatment of human tauopathies.
Source: Acta Neuropathologica - Category: Neurology Source Type: research

Related Links:

Conclusions We found a contextual preventive effect of community-level sports group participation on developing cognitive impairment among older individuals. Furthermore, the benefit may favor sports group participants. Therefore, promoting sports groups in a community setting may be effective as a population-based strategy for the prevention of dementia.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: EPIDEMIOLOGY Source Type: research
CONCLUSION: AD causes impairment of EnA and ExA. Faster reactions by AD participants to the target on the left in VT+s and more accurate reactions to the target on the left in VT-s are in agreement with reports in the literature on the lateralization of visual-spatial attention (VSA) in the right hemisphere. In this study, also in agreement with previous reports, lateralization in AD was noted in favour of the stimuli on the left in ExA. PMID: 31613976 [PubMed - in process]
Source: Turkish Journal of Psychiatry - Category: Psychiatry Authors: Tags: Turk Psikiyatri Derg Source Type: research
DISCUSSION: Aβ misfolding in blood plasma was a strong, specific risk prediction marker for clinical AD even many years before diagnosis in a community-based setting. PMID: 31611055 [PubMed - as supplied by publisher]
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Authors: Lee G, Cummings J, Decourt B, Leverenz JB, Sabbagh MN Abstract Introduction: Dementia with Lewy bodies (DLB) is an under-researched area despite being the second most common type of degenerative dementia after Alzheimer's disease. It is an area of unmet need with no approved symptomatic or disease-modifying therapies. The pharmacological management of DLB is complex and challenging because early trials of drugs for DLB have resulted in no demonstrable efficacy. Randomized controlled trials (RCTs) in the DLB population have only recently been initiated. Understanding results from previous and current clinic...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Source: Acta Neuropathologica - Category: Neurology Source Type: research
AbstractObjectivesPeople living with dementia (PWD) frequently receive medicine regularly from their community pharmacy, thus providing an opportunity to address either directly or through a carer any unmet medicine ‐related needs. The aim of this systematic review was to identify, describe, and evaluate the quality of the research for dementia‐specific pharmacy‐based interventions with potential for delivery through community pharmacy. This would inform the design of future services and associated trial s.Key FindingsThe systematic review process identified 29 studies. Interventions were categorised as medicati...
Source: International Journal of Pharmacy Practice - Category: Drugs & Pharmacology Authors: Tags: Review Article Source Type: research
Statins for primary prevention in people at low risk of CVD might be low-value care and waste of healthcare resources Related items fromOnMedica Pharmacists could offer high-dose statins direct to patients UK research reveals racial inequalities in diabetes care Fund specialist dementia training to improve care and save money NHS must improve access to screening to save lives Prescription drug dependence linked to deprivation
Source: OnMedica Latest News - Category: UK Health Source Type: news
Previous functional imaging studies have identified the role of central autonomic network (CAN) in autonomic regulation during various tasks. However, its variability with respect to gender and age, particularly in the resting state, remains poorly understood. Therefore, in this study we systematically investigated gender- and age-related differences in the resting-state functional connectivity (rsFC) seeded from core regions of this network, namely posterior mid-cingulate gyrus (pMCC), left amygdala, right anterior and left posterior insula, and ventromedial prefrontal cortex (vmPFC), using a large cross-sectional adultho...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
One of the most commonly asked questions about cognitive issues is “Is it Alzheimer’s or dementia?” The short answer is, Alzheimer’s is one type of dementia. According to the Alzheimer’s Association, “Dementia is a general term for loss of memory and other mental abilities severe enough to interfere with daily life. It is caused by physical changes in the brain.” The National Institutes of Health says that some types of dementia can be stopped or reversed with treatment. View the slideshow on HealthCentral to learn more about the different types of dementia: Carol is the Candi...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Sometimes you don’t realize you’ve been drowning until the moment you’re pulled to safety, gulping fresh air again. Like others who’ve battled depression, I didn’t fully comprehend how dark I felt while muddling through it.  Even in my darkest moments, I tried to pretend everything was fine. I’d been raised to be strong and capable during a crisis — to count my blessings and refrain from complaining. Never wanting to burden my family or friends, I often hid my pain. And the more I tried to downplay my sadness, the more isolated I felt.  The terrible se...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Caregivers Personal Burnout caregiving Depression Elderly Self Care Source Type: blogs
More News: Brain | Dementia | Neurology