FDA Approves Optune In Combination With Temozolomide For The Treatment Of Newly Diagnosed Glioblastoma
Novocure has announcedthat the FDAhas approved Optune in combination with temozolomide for the treatment of adult patients with newly diagnosed glioblastoma (GBM). Optune is a portable, non-invasive device that delivers low-intensity, intermediate frequency, alternating electric fields – referred to as Tumor Treating Fields (TTFields) – that inhibit cancer cell replication and cause cancer cell death.
Markus Schosserer, Johannes Grillari, Michael Breitenbach
Alan Dal Pra, Thomas Zilli, Stephane Supiot
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Adebola Giwa, Rizwan Ahmed, Thomas Donner, Hideo Yagita, Abdel Rahim A. Hamad
This amount cuts the risk of heart disease by 15% and early death by 17%, found the University of Southampton. It also slashes chances of certain cancers, diabetes, liver disease and dementia.
Conclusions: miR-27a, miR-27b, miR-9, miR10a and miR-10b were up-regulated in PDAC cells compared to HPDE cells. The up-regulation of these miRNAs was not responsible for the down-regulation of RAR α, RARβ, RXRα and RXRβ in PDAC cells.Cell Physiol Biochem 2017;44:644 –656
Conclusion: Our results support the hypothesis that CAV-1 knockdown by siRNA causes increased radiosensitivity in basal-like TNBC cells. The mechanisms associated with this effect are reduced DNA repair through delayed CAV-1-associated EGFR nuclear accumulation and induction ofG2/M arrest and apoptosis through the combined effects of CAV-1 siRNA and radiation.Cell Physiol Biochem 2017;44:778 –791
Conclusion: Taken together, melatonin has different antioxidative effects on tumour cells compared to non-tumour ones; it also differs in the ability to induce apoptosis through the type 1 sodium/calcium exchanger, and type 1 IP3 receptor. Different targeting of calcium transport systems in tumour and normal, non-tumour cells is suggested as a key mechanism how melatonin can exert its anticancer effects. Therefore, it might have a potential as a novel therapeutic implication in cancer treatment.Cell Physiol Biochem 2017;44:763 –777