Difference in stroke incidence between Korean and Japanese patients initiating dialysis — era or ethnic effect?

We thank Tomoyuki Kawada for the letter in response to our recent article [1]. First, we would like to focus on the differences in epidemiologic characteristics of stroke between our study population and those enrolled in a previous study conducted in Japan [2]. As indicated, the main difference in the findings between the two studies was that the proportion of hemorrhagic stroke among the total stroke events was substantially higher in the Japanese study than in our study (52% vs. 21%). Although the definite reasons for this difference remain uncertain, adding to the possible association kindly suggested by Kawada, some supplementary explanations have been extrapolated from previous studies in the general population not receiving dialysis treatment.
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Correspondence Source Type: research

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Purpose of review Direct oral anticoagulants (DOACs) are variably eliminated by the kidneys rendering their use potentially problematic in patients with chronic kidney disease (CKD) or necessitating appropriate dose adjustment. Recent findings Both observational and limited randomized trial data for DOACs compared with no treatment or with warfarin for patients with atrial fibrillation on maintenance dialysis were recently published. In a randomized trial in patients on hemodialysis, there was no significant difference in vascular calcification between patients who received rivaroxaban with or without vitamin K2 or vi...
Source: Current Opinion in Nephrology and Hypertension - Category: Urology & Nephrology Tags: PHARMACOLOGY AND THERAPEUTICS: Edited by Sankar D. Navaneethan Source Type: research
CONCLUSIONS: In patients with kidney failure and nonvalvular atrial fibrillation, treatment with apixaban was not associated with a lower incidence of new stroke, transient ischemic attack, or systemic thromboembolism but was associated with a higher incidence of fatal or intracranial bleeding. PMID: 32444398 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - Category: Urology & Nephrology Authors: Tags: Clin J Am Soc Nephrol Source Type: research
CONCLUSION: Despite significant functional and neurological improvements following rehabilitation, stroke patients with underlying CKD had higher average duration of hospital stay, more recurrent hospitalisations and poorer survival outcomes than those without underlying CKD. This could be attributed to the complications associated with CKD rather than stroke. Multidisciplinary community rehabilitation may be an alternative to reduce recurrent hospitalisations and morbidity in this group of patients. PMID: 32241068 [PubMed - as supplied by publisher]
Source: Singapore Medical Journal - Category: General Medicine Authors: Tags: Singapore Med J Source Type: research
Publication date: Available online 3 March 2020Source: Interdisciplinary NeurosurgeryAuthor(s): Harsh Deora, Nishant S Yagnick, Sandeep Moolchandani, Manoranjan Sharma, Vivek Tomar, Manjul Tripathi, Sumit Sinha, V.S. Mehta
Source: Interdisciplinary Neurosurgery - Category: Neurosurgery Source Type: research
CONCLUSION: In patients with ESRD undergoing dialysis, PD had lowered risks of new onset of AF compared to HD. Subsequently, these AF patients in PD group had comparable incidence of ischemic stroke but decreased incidence of hemorrhagic stroke compared to AF patients in HD group. PD could be the most suitable modality in patients at risk for the onset of AF. PMID: 32086785 [PubMed - as supplied by publisher]
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
The aim of this study is to examine factors that can predict mortality in patients that have veno-arterial extracorporeal membrane oxygenation (VA-ECMO) instituted for cardiogenic shock. A single-center, retrospective study of 127 patients who underwent VA-ECMO for cardiogenic shock between January 2003 and December 2017 was conducted. Eighty-three (65%) patients survived to weaning or bridging therapy. Complications on VA-ECMO include: hemorrhage (40%), stroke (14%), requirement for dialysis (42%), and limb ischemia (24%). Univariate analysis revealed shorter ECMO duration, higher body mass index, preimplantation creatini...
Source: ASAIO Journal - Category: Medical Devices Tags: Adult Circulatory Support Source Type: research
Her words hung in the hushed air.“Thank you for saving our boy,” the mother said, her voice choked by emotion.Devra Schwartz, and her husband, Jeff, recently had a chance to express their gratitude to eight of the 100 strangers whose blood donations provided a lifeline for their son, Judah, now 4. The Santa Monica youngster nearly died last year when his kidneys failed due to foodborne E. coli infection.Toxins in the E. coli bacteria ruptured Judah ’s red blood cells, leading to massive blood loss. His platelets — critical to clotting and preventing hemorrhage — plummeted to 13,000. A healthy ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
AbstractHemolytic uremic syndrome is commonly caused by Shiga toxin-producingEscherichia coli (STEC). Up to 15% of individuals with STEC-associated hemorrhagic diarrhea develop hemolytic uremic syndrome (STEC HUS). Hemolytic uremic syndrome (HUS) is a disorder comprising of thrombocytopenia, microangiopathic hemolytic anemia, and acute kidney injury. The kidney is the most commonly affected organ and approximately half of the affected patients require dialysis. Other organ systems can also be affected including the central nervous system and the gastrointestinal, cardiac, and musculoskeletal systems. Neurological complicat...
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research
Conclusions: Among patients with incident PD, a higher serum Lp(a) level may predict a lower risk of hemorrhagic stroke. PMID: 31498021 [PubMed - in process]
Source: Renal Failure - Category: Urology & Nephrology Tags: Ren Fail Source Type: research
This study was to explore their associations in a large PD cohort.MethodsThis retrospective cohort study included incident patients received PD catheter insertion in our center. The primary outcome was the first CV event (non-fatal myocardial infarction, CV death, non-haemorrhagic stroke, or any arterial revascularisation procedure). Secondary outcomes were occurrence of peritonitis, CV mortality, and all-cause mortality.ResultsThis study included 1294 patients, whose mean age was 48.1 years. After adjustment for confounders in Negative binomial regression models, lower LDL-C quartiles were independently associated with a ...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
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