IL-1β promotes ADAMTS enzyme-mediated aggrecan degradation through NF-κB in human intervertebral disc

Conclusions:
By controlling the activation of NF-κB signaling, IL-1β modulates the expression of ADAMTS in NP cells. To our knowledge, this is the first study that shows the contribution of both ADAMTS-4 and ADAMTS-5 to aggrecan degradation in human NP cells.

Source: Journal of Orthopaedic Surgery and Research - October 6, 2015 Category: Orthopaedics Authors: Zhongyi SunZhanmin YinChao LiuHe LiangMinbo JiangJiwei Tian Source Type: research