NovoCure wins expanded indications for Optune brain tumor-zapping device

NovoCure said it won expanded indications from the FDA and a new CE Mark indication in the European Union for its brain-tumor treating Optune device. The Optune device uses NovoCure’s “tumor treating fields,” which use low-intensity, intermediate-frequency alternating electric fields that limit cancer cell replication and kill cancer cells, the St. Helier, N.J.-based company said. The FDA granted NovoCure clearance for its Optune in combination with prescribed temozolomide for the treatment of adult patients with newly diagnosed glioblastomas. “Novocure is committed to helping patients with glioblastoma, and we are proud that Optune has been shown to offer patients such a significant improvement in both progression-free and overall survival. Glioblastoma is the most common form of primary brain cancer which, until now, has not seen any significant therapeutic improvements in over a decade. We’re thankful to the many patients, their caregivers and healthcare providers who partnered with us to develop a treatment that has finally led to a significant improvement in the outcomes for patients with glioblastoma,” CEO Asaf Danziger said in a press release. The clinical study that supported the expanded indication reported that patients treated with the device and drug lived an average of 3 months longer than those who only took the drug, the company said. The new indication was reviewed under the FDA’s priority review program which provides...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Food & Drug Administration (FDA) Oncology Radiosurgery Regulatory/Compliance NovoCure Source Type: news

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In conclusion, the present study demonstrated that FOXK1 promoted cell growth through activating wnt/β-catenin pathway and is negatively regulated by miR-137 in glioma. PMID: 30018719 [PubMed]
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
Publication date: 5 September 2018Source: International Journal of Pharmaceutics, Volume 548, Issue 1Author(s): Mengnan Zhao, Fabienne Danhier, Chiara Bastiancich, Nicolas Joudiou, Lakshmi Pallavi Ganipineni, Nikolaos Tsakiris, Bernard Gallez, Anne des Rieux, Aleksandar Jankovski, John Bianco, Véronique PréatAbstractGlioblastoma multiforme (GBM) is the most common primary malignant brain tumor. Despite available therapeutic options, the prognosis for patients with GBM remains very poor. We hypothesized that the intra-operative injection of a photopolymerizable hydrogel into the tumor resection cavity could su...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
(Oxford University Press USA) A new study in the Journal of the National Cancer Institute suggests that CT scans, commonly used in medical imaging, may increase the risk of brain tumors.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
(The Translational Genomics Research Institute) A tissue donation portal opened today at TGen, which will advance research towards new treatments for an aggressive brain cancer that mostly strikes young children. This new portal will accelerate the ability of families of children with DIPG -- or Diffuse Intrinsic Pontine Glioma -- to help TGen build a tissue bank that will aid researchers in their investigations of this rare and currently incurable disease that strikes about 350 children in the US each year.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
uárez César Sanz Roberto Sarmiento The use of hyperspectral imaging (HSI) in the medical field is an emerging approach to assist physicians in diagnostic or surgical guidance tasks. However, HSI data processing involves very high computational requirements due to the huge amount of information captured by the sensors. One of the stages with higher computational load is the K-Nearest Neighbors (KNN) filtering algorithm. The main goal of this study is to optimize and parallelize the KNN algorithm by exploiting the GPU technology to obtain real-time processing during brain cancer surgical procedures. Thi...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
ConclusionsOur findings are not consistent with a discernable effect of cellphone use patterns in Israel on incidence trends of brain, CNS and intracranial tumors.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Investigators at the NCI Laboratory of Immune Cell Biology  discovered an Anti-TNF Induced Apoptosis (ATIA) protein, which protects cells against apoptosis.  ATIA is highly expressed in glioblastoma and astrocytomas and its inhibition results in increased cell sensitivity to TNF-related apoptosis-inducing ligand induced cell death.  Hence, ATIA assays ma y enable clinicians to effectively stratify patients for appropriate treatment.  ATIA exists in a soluble form that can be detected in culture medium of ATIA expressing cells indicating it could be used to develop a non-invasive, blood based diagnostic ...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
Authors: Sun S, Du G, Xue J, Ma J, Ge M, Wang H, Tian J Abstract Indoleamine 2,3-dioxygenase (IDO), which is highly expressed in human glioblastoma and involved in tumor immune escape and resistance to chemotherapy, is clinically correlated with tumor progression and poor clinical outcomes, and is a promising therapeutic target for glioblastoma. IDO inhibitors are marginally efficacious as single-agents; therefore, combination with other therapies holds promise for cancer therapy. The aim of this study was to investigate the anti-tumor effects and mechanisms of the IDO inhibitor PCC0208009 in combination with temoz...
Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research
Abstract Glioblastoma multiforme (GBM) is a highly aggressive and heterogeneous form of primary brain tumors, driven by a complex repertoire of oncogenic alterations, including the constitutively active epidermal growth factor receptor (EGFRvIII). EGFRvIII impacts both cell-intrinsic and non-cell autonomous aspects of GBM progression, including cell invasion, angiogenesis and modulation of the tumor microenvironment. This is, at least in part, attributable to the release and intercellular trafficking of extracellular vesicles (EVs), heterogeneous membrane structures containing multiple bioactive macromolecules. He...
Source: Molecular and Cellular Proteomics : MCP - Category: Molecular Biology Authors: Tags: Mol Cell Proteomics Source Type: research
In this study, human glioma U251 cells and rat glioma C6 cells were treated with different concentrations of β-asarone. Cultured them for 24 h, 48 h, 72 h and evaluated the IC50 with the results of Counting Kit-8 assay. Then, cell apoptosis and cell DNA cycles were evaluated with flow cytometry. Apoptosis related mRNA and protein were analyzed In addition, cell migration and invasion were also detected with wound healing and transwell assays, respectively. What is more, glioma specific proteins: GFAP, NRP-1 and NSE an enzyme-linked immunosorbent assay. The corresponding CCK-8 results showed that β-asarone a...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
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