Targeting Treg signaling for the treatment of autoimmune diseases.

Targeting Treg signaling for the treatment of autoimmune diseases.
Curr Opin Immunol. 2015 Sep 29;37:11-20
Authors: Spence A, Klementowicz JE, Bluestone JA, Tang Q
Abstract
Regulatory T (Treg) cells are crucial players in the prevention of autoimmunity. Treg lineage commitment and functional stability are influenced by selected extracellular signals from the local environment, shaped by distinctive intracellular signaling network, and secured by their unique epigenetic profile. Recent advances in our understanding of the complex processes of Treg lineage differentiation, maintenance, and function has paved the way for developing strategies to manipulate these important cells for therapeutic benefit in many diseases. In this review, we will summarize recent advances in our understanding of Treg biology as well as Treg-targeted therapies in the context of autoimmune disease.
PMID: 26432763 [PubMed - as supplied by publisher]

Source: Current Opinion in Immunology - September 29, 2015 Category: Allergy & Immunology Authors: Spence A, Klementowicz JE, Bluestone JA, Tang Q Tags: Curr Opin Immunol Source Type: research