Long-term stable lung function and second uncomplicated pregnancy on sirolimus in lymphangioleiomyomatosis (LAM).

In conclusion, the second pregnancy on uninterrupted sirolimus was uncomplicated both with respect to mother and child suggesting that sirolimus at the dose used may be safe in pregnant patients with LAM. During pregnancy, blood levels of sirolimus declined spontaneously indicating a faster metabolism of the drug. However, even at sirolimus levels considered subtherapeutic in the MILES trial, lung function was preserved during pregnancy in this patient. Since the vast majority of LAM patients are young women with a much improved outcome on sirolimus, a significant number may wish to become pregnant. However, in LAM trials, in particular in the MILES trial, pregnant women are excluded. Therefore, it is important to systematically collect information on the outcome of LAM during pregnancy. PMID: 26422572 [PubMed - in process]
Source: Sarcoidosis Vasculitis and Diffuse Lung Diseases - Category: Respiratory Medicine Tags: Sarcoidosis Vasc Diffuse Lung Dis Source Type: research