Upregulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice
Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic manifestation of the metabolic syndrome, which is characterized by insulin resistance, dyslipidemia, hypertension and type 2 diabetes [1,2]. It occurs mainly due to fat accumulation in the liver, and can lead to cirrhosis, which is not reversible and may ultimately progress to hepatocellular carcinoma (HCC) [3,4]. Several population-based studies have demonstrated that the prevalence of NAFLD in premenopausal women is lower than that in men between the ages of 20 and 50years, and also lower than in postmenopausal women [5,6].
A highly selective and sensitive detection of insulin with chemiluminescence biosensor based on aptamer and oligonucleotide-AuNPs functionalized nanosilica @ graphene oxide aerogel. Anal Chim Acta. 2019 Dec 16;1089:152-164 Authors: Sun Y, Lin Y, Sun W, Han R, Luo C, Wang X, Wei Q Abstract A novel, highly selective and sensitive chemiluminescence (CL) biosensor for insulin (INS) detection was proposed based on aptamer and oligonucleotide-gold nanoparticles functionalized nanosilica @ graphene oxide aerogel. Initially, nanosilica functionalized graphene oxide aerogel (SiO2@GOAG) was successfully pr...
This study identifies patterns of alcohol consumption in youth and investigates how these patterns vary across schools and whether individual- a...
Middle aortic syndrome is a rare condition characterized by coarctation of distal thoracic or abdominal aorta with involvement of the major branches; therefore, the lesions are particularly difficult to manage. More experience in its treatment is required to establish a well-supported treatment guideline. This retrospective study of the clinical and anatomic characteristics of patients with middle aortic syndrome as well as their treatment details and outcomes was conducted in a single center.
This study aimed to review chara cteristics of multicultural Asian diabetic patients presenting to tertiary care with peripheral vascular complications and subsequent intervention rates and outcomes.
The objective of this study was to review the outcomes after split-thickness skin grafting (SSG) of patients with peripheral artery disease and diabetic foot wounds in an Asian population.
Diabetic foot ulcer (DFU) is a major health problem and remains a major cause of amputation across the world. Critical assessment of the relationship between peripheral artery disease, revascularization, and healing of DFU was performed. A new therapy has been claimed to prevent major amputations in advanced DFU. The intralesional injection of recombinant human epidermal growth factor (EGF) should often lead to satisfactory outcomes. The purpose of our study was to demonstrate the advantage of the combination of revascularization and EGF local infiltration in accelerating healing of DFU.
This report aimed to discuss the reason for IVCT in a case of pregnancy-induced hypertension with decreased antithrombin III and protein S and the anticoagulation strategy.
This study was designed to investigate whether angiogenesis factors could serve as noninvasive markers for the diagnosis of PH in the COPD patient and which could serve as therapeutic targets.
AbstractPurpose of ReviewIn this review, we examine the interaction between the metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) and describe the impact of the features of MS on the most worrisome complications of non-alcoholic steatohepatitis (NASH), (cirrhosis, hepatocellular carcinoma) and, ultimately, on liver-related, cardiovascular, and overall mortality.Recent FindingsInsulin resistance, obesity, and dyslipidemia in a pro-inflammatory environment have a causal role in hepatic fibrogenesis and oncogenesis in NAFLD patients. Natural history, longitudinal studies confirm the conditions linked to MS...
Conclusions: As the global epidemic of obesity fuels metabolic conditions, the clinical and economic burden of NAFLD will become enormous. (Hepatology 2015)
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