Upregulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice

Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic manifestation of the metabolic syndrome, which is characterized by insulin resistance, dyslipidemia, hypertension and type 2 diabetes [1,2]. It occurs mainly due to fat accumulation in the liver, and can lead to cirrhosis, which is not reversible and may ultimately progress to hepatocellular carcinoma (HCC) [3,4]. Several population-based studies have demonstrated that the prevalence of NAFLD in premenopausal women is lower than that in men between the ages of 20 and 50years, and also lower than in postmenopausal women [5,6].
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Research Article Source Type: research

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A highly selective and sensitive detection of insulin with chemiluminescence biosensor based on aptamer and oligonucleotide-AuNPs functionalized nanosilica @ graphene oxide aerogel. Anal Chim Acta. 2019 Dec 16;1089:152-164 Authors: Sun Y, Lin Y, Sun W, Han R, Luo C, Wang X, Wei Q Abstract A novel, highly selective and sensitive chemiluminescence (CL) biosensor for insulin (INS) detection was proposed based on aptamer and oligonucleotide-gold nanoparticles functionalized nanosilica @ graphene oxide aerogel. Initially, nanosilica functionalized graphene oxide aerogel (SiO2@GOAG) was successfully pr...
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Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
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AbstractPurpose of ReviewIn this review, we examine the interaction between the metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD) and describe the impact of the features of MS on the most worrisome complications of non-alcoholic steatohepatitis (NASH), (cirrhosis, hepatocellular carcinoma) and, ultimately, on liver-related, cardiovascular, and overall mortality.Recent FindingsInsulin resistance, obesity, and dyslipidemia in a pro-inflammatory environment have a causal role in hepatic fibrogenesis and oncogenesis in NAFLD patients. Natural history, longitudinal studies confirm the conditions linked to MS...
Source: Current Hepatitis Reports - Category: Infectious Diseases Source Type: research
Conclusions: As the global epidemic of obesity fuels metabolic conditions, the clinical and economic burden of NAFLD will become enormous. (Hepatology 2015)
Source: Hepatology - Category: Internal Medicine Authors: Tags: Steatohepatitis and Metabolic Liver Disease Source Type: research
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