Is there anything against Abscessus when Tygacil, Amikacin etc have failed?

Hi all, With some desperation, I am looking for some support and ideas on this forum. I have been hospitalized now 3 times for abscessus infection the last 8 years. The first 2 times I bounced back each time a bit after 11 and 6 months hospitalization, thanks to Tygacil which was just on the market. ANd then I stayed out of hospital for 3 years each time. After the birth of my daughter (a miracle!! Thx Gd!), I started crashing and was hospitalized 5 months ago. Unfortunately my abscessus is nowadays resistant against all commonly used drugs such clarithromycin,cefoxitin, moxifloxacin clofamicin,amikacin,meropenem and now also to tygacil. After 5 months in hospital I was discharged this week, as basically there are no options left and the meropenem, amikacin,clarithromycin, tygacil cocktail showed now progress. So I am in worse shape now as I was when i entered hospital and I am really scared big time. I have a 7 months old daughter and sometimes I fear I will not see here become 1 or 2 years. ALso because transplant is not allowed for abcessus patients. So I am just wondering if anyone has heard about or has has any experience with any investigational drugs (e.g.bedaquiline) or is on a special regime or has some nice ideas about alternative or supplemental medication. Anything will be much appreciated!! Thanks a lot and sorry for the melodramatic tone in my message..I am almost 40 and for first time really scared as s...t Warm regards Jeanpaul FEV1: 1,0 ltr, Df508 and E528...
Source: Cystic Fibrosis Adults Forum - Category: Respiratory Medicine Authors: Tags: Adults Source Type: forums