CRT's Obesity Paradox in HF: Long-Term Survival Rises With BMICRT's Obesity Paradox in HF: Long-Term Survival Rises With BMI

Widely recognized but poorly understood, the inverse relationship between heart failure mortality and BMI applies to patients on cardiac resynchronization therapy and may extend at least a decade. Heartwire from Medscape
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Cardiology News Source Type: news

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AbstractHeart failure with reduced ejection fraction (HFrEF) is common in patients with adult congenital heart disease. Many of the most common congenital defects have a high prevalence of HFrEF, including left-sided obstructive lesions (aortic stenosis, coarctation of the aorta, Shone complex), tetralogy of Fallot, Ebstein anomaly, lesions in which there is a systemic right ventricle, and lesions palliated with a Fontan circulation. However, heart failure with preserved ejection fraction (HFpEF) is also prevalent in all these lesions. Comprehensive evaluation includes physical exam, biomarkers, echocardiography and advanc...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
, Jacobo-García K, Cossio-Aranda J Abstract Heart failure (HF) is a syndrome characterized basically by a circulatory deficit to cover the metabolic and energetic demands of the body. This condition has a broad spectrum in its clinical presentation, affects the quality of life significantly, impacts the family/social environment, and generates a great demand for health services. The purpose of this research is to report the situational diagnose of patients with HF in Mexico. We evaluated 292 patients, 70.2% were men. Average age was 56.7 ± 14.3 years. Ischemic heart disease is the main etiology (98 p...
Source: Archivos de Cardiologia de Mexico - Category: Cardiology Authors: Tags: Arch Cardiol Mex Source Type: research
AimsTo assess the association of body mass index (BMI) with heart failure (HF) outcomes after cardiac resynchronization therapy with defibrillator (CRT ‐D) implantation.Methods and resultsMedicare beneficiaries with HF aged ≥ 65 years (n = 18 922) undergoing first‐time CRT‐D from the National Cardiovascular Data Registry (NCDR) Implantable Cardioverter‐Defibrillator Registry between 2010 and 2013, were followed for 3 years post‐implantation. Survival curves and covariate adjusted hazard ratio (aHR) or odds ratio were used to assess the risks for death, readmission, and dev...
Source: European Journal of Heart Failure - Category: Cardiology Authors: Tags: Research Article Source Type: research
Yolanda Benito1, Pablo Martinez-Legazpi1*, Lorenzo Rossini2, Candelas Pérez del Villar1, Raquel Yotti1, Yolanda Martín Peinador3, Daniel Rodríguez-Pérez4, M. Mar Desco4, Constancio Medrano1, Jose Carlos Antoranz4, Francisco Fernández-Avilés1, Juan C. del Álamo2,5 and Javier Bermejo1 1Department of Cardiology, Hospital General Universitario Gregorio Marañón, Facultad de Medicina, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Gregorio Marañón and CIBERCV, Madrid, Spain 2Department of Mechanical and Aerospace ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusion: This study observed an inverse correlation between plasma LDL cholesterol and heart function in individuals with T2DM. Patients with higher levels of plasma LDL cholesterol had worse left ventricular function. Therefore, plasma LDL cholesterol may be a modifiable risk factor of heart failure in diabetes, but prospective studies are necessary to confirm this finding. Introduction Type 2 diabetes mellitus (T2DM) is a metabolic disease that affects a considerable number of patients worldwide (1). Among diabetic individuals, cardiovascular disease (CVD) is the leading cause of morbidity and mortality (2). C...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Obesity confers a paradoxical survival benefit among patients with heart failure (HF), but this obesity paradox has not been well established in patients undergoing cardiac resynchronization therapy with a defibrillator (CRT-D). We sought to determine the impact of body mass index (BMI) on long-term survival in patients with HF following CRT-D. We identified 113 patients implanted with CRT-D at our institution from 5/2002-11/2003. Patients were divided into three categories by pre-implant BMI (kg/m2): normal-weight (BMI
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
Abstract BACKGROUND: Although association of metabolic syndrome (MS) and ischemic heart disease is strongly established, it is not known if presence of MS may differently influence clinical responses to CRT. The aim of this study was to evaluate the associations between obesity and metabolic features and the clinical outcome after cardiac resynchronization with defibrillator therapy (CRT-D) compared to an implantable cardioverter defibrillator (ICD). METHODS AND RESULTS: The risk of heart failure (HF) or death and death alone was evaluated in 829 non-obese patients, 156 obese patients without MS, and 277 obes...
Source: Cardiology Journal - Category: Cardiology Authors: Tags: Cardiol J Source Type: research
Previous studies have demonstrated that obesity confers a paradoxical survival benefit among patients with heart failure (HF). This obesity paradox has been described in HF patients undergoing cardiac resynchronization therapy with a defibrillator (CRT-D), but these studies have been restricted to short-term follow-up.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: Rapid-Fire Abstracts I Source Type: research
This study aimed to examine the association between body mass index (BMI) and prognosis in heart failure patients after cardiac resynchronization therapy-defibrillator (CRT-D) implantation. Methods We retrospectively investigated 125 patients (33 overweight [BMI ≥25 kg/m2], 75 normal weight [BMI 18.5–24.9 kg/m2], and 17 underweight patients [BMI
Source: Journal of Interventional Cardiac Electrophysiology - Category: Cardiology Source Type: research
A 73-year-old man presented to the cardiology clinic in early fall for evaluation of shortness of breath that had worsened over the previous year. He had numerous comorbidities, including hypertension, hyperlipidemia, type 2 diabetes mellitus, medically complicated obesity, stage 3 chronic kidney disease, obstructive sleep apnea, and a 10-year history of nonischemic cardiomyopathy after biventricular pacemaker placement for cardiac resynchronization therapy (CRT). He was receiving maximal medical therapy for his heart failure.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Residents’ clinic Source Type: research
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