Silvina Luna is left infertile and in constant pain after botched surgery
Silvina Luna, pictured, from Argentina, is now suing the man who calls himself the 'surgeon of the star' after the controversial process left her with serious kidney damage.
We present a case depicting a 63 year-old woman who presented with an apparent inguinal hernia in 2017; she was ultimately diagnosed with a pelvic side wall clear cell carcinoma with metastatic disease to the medial groin, which emanated from endometriosis. Malignant transformation of endometriosis identified in the pelvic side wall is a very rare finding. Nevertheless, oncologists should maintain a high index of suspicion in patients with a history of endometriosis or prior pelvic surgery.
Leiomyoma can lead to significant morbidity in reproductive-aged women, causing symptoms that range from bleeding and pain to infertility. Despite recent progress made regarding tumor mitogens and nonsurgical treatments, the exact pathogenesis of fibroids remains unknown. Prolactin has been implicated as a mitogen growth factor in leiomyoma. Antipsychotic medications, in lowering dopamine levels and thereby removing the inhibition of prolactin secretion, can increase serum prolactin levels. Given this relationship, it stands to reason that antipsychotics may have a deleterious effect on myometrial smooth muscle cells.
Conditions: Anesthesia; Infertility; Pain, Postoperative; Stress, Psychological Intervention: Sponsors: Yavuz Orak; Kahramanmaras Sutcu Imam University Active, not recruiting
Conclusion: NR4A1 can regulate fibrosis in endometriosis and may serve as a new target for the treatment of endometriosis.Cell Physiol Biochem 2018;46:1078 –1090