Synthetic Double-Stranded RNA Poly(I:C) Aggravates IgA Nephropathy by Triggering IgA Class Switching Recombination through the TLR3-BAFF Axis.

CONCLUSION: These data points toward the role of TLR3/BAFF axis in IgA CSR of IgAN, and the data also support the notion that mucosal immunization with virus infection results in impaired mucosal and systemic IgA responses.
PMID: 26417991 [PubMed - as supplied by publisher]

Source: American Journal of Nephrology - September 30, 2015 Category: Urology & Nephrology Authors: He L, Peng X, Wang J, Tang C, Zhou X, Liu H, Liu F, Sun L, Peng Y Tags: Am J Nephrol Source Type: research