An Enlarging Liver in a Young Diabetic Male

Question: A 22-year-old man with history of type 1 diabetes mellitus, alpha-1-antitrypsin deficiency (ZZ phenotype), gastroesophageal reflux disease, hyperlipidemia, and depression presented to the hospital for increasing right upper quadrant pain and nausea for 2 weeks. The patient was a former heroin user and an active smoker, but denied significant alcohol use. The patient’s home medications included insulin, atorvastatin, dexlansoprazole, paroxetine, buprenorphine, and trazodone. The patient had poorly controlled diabetes, requiring 6 hospitalizations for diabetic ketoacidosis within the last year.
Source: Gastroenterology - Category: Gastroenterology Authors: Tags: Electronic Clinical Challenges and Images in GI Source Type: research

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Publication date: Available online 24 January 2020Source: Journal of Genetics and GenomicsAuthor(s): Qianru Huang, Xu Liu, Yujia Zhang, Jingyao Huang, Dan Li, Bin LiAbstractRegulatory T (Treg) cells, a subtype of CD4+ T cells with distinct immunosuppressive, are vital for maintaining immune homeostasis in healthy people. FOXP3 (Forkhead box protein P3), a member of the forkhead–winged-helix family, is the pivotal transcriptional factor of Treg. The expression, post-translational modifications and protein complex of FOXP3 present a great impact on the functional stability and immune plasticity of Treg in vivo. In part...
Source: Journal of Genetics and Genomics - Category: Genetics & Stem Cells Source Type: research
PMID: 31977420 [PubMed - in process]
Source: The American Journal of Nursing - Category: Nursing Authors: Tags: Am J Nurs Source Type: research
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Source: Social Work in Health Care - Category: International Medicine & Public Health Authors: Source Type: research
Publication date: Available online 24 January 2020Source: Arthroscopy TechniquesAuthor(s): Jeong Woo Kim, Dae Jin NamAbstractThe treatment of massive and irreparable rotator cuff tears remains a challenge for shoulder surgeons. When treating patients with chronic rotator cuff tears, especially those with severe fatty degeneration, severe tendon retraction, or muscle atrophy, the risk of re-tear and persistent severe pain persists. Therefore, surgeons can choose from numerous options. Superior capsular reconstruction (SCR) was introduced as a technique to maintain the stability of the upper shoulder and stabilize the muscle...
Source: Arthroscopy Techniques - Category: Surgery Source Type: research
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Source: Journal of Sports Sciences - Category: Sports Medicine Authors: Source Type: research
Publication date: Available online 25 January 2020Source: Best Practice &Research Clinical RheumatologyAuthor(s): Ay┼če A. KüçükdeveciAbstractThe goals in the management of established rheumatoid arthritis (RA) are to control pain and disease activity, prevent further joint damage, and enhance functioning and quality of life. Despite the fact that aggressive and the early use of biological and nonbiological disease-modifying antirheumatic drugs have been associated with substantial gains in clinical, radiological, and disability outcomes, a considerable proportion of patients still report significant p...
Source: Best Practice and Research Clinical Rheumatology - Category: Rheumatology Source Type: research
Publication date: Available online 24 January 2020Source: International Journal of PsychophysiologyAuthor(s): Peter E. Clayson, Kaylie A. Carbine, Michael J. LarsonAbstractPerformance-monitoring event-related brain potentials (ERPs), such as the error-related negativity (ERN) and reward positivity (RewP), are advocated as biomarkers of depression symptoms and risk. However, a recent meta-analysis indicated effect size heterogeneity in the ERN and RewP literatures. Hence, advocating these ERPs as biomarkers of depression might be premature or possibly misguided due to the selective reporting of significant analyses on the p...
Source: International Journal of Psychophysiology - Category: Psychiatry & Psychology Source Type: research
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Source: Journal of Gerontological Nursing - Category: Nursing Authors: Tags: J Gerontol Nurs Source Type: research
This article reviews the state of the art and major unanswered questions related to ocular vascular anatomy and physiology, ocular imaging techniques, clinical findings in glaucoma and other eye diseases, and mechanistic modeling predictions, while laying a path for integrating clinical observations with mathematical models and artificial intelligence. Viable alternatives for integrated data analysis are proposed that aim to overcome the limitations of standard statistical approaches and enable individually tailored precision medicine in ophthalmology.
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Publication date: Available online 25 January 2020Source: PharmaNutritionAuthor(s): F. Tomazini, A.C. Santos-Mariano, V.A. Andrade-Souza, V.C. Sebben, C.A. De Maria, D.B. Coelho, R. Bertuzzi, M.D. Silva-Cavalcante, A.E. Lima-SilvaAbstractAcetaminophen has been combined with caffeine for therapeutic purpose, but the effect of co-ingestion of acetaminophen and caffeine on exercise performance has not been investigated. To determine the effect of isolated and combined ingestion of caffeine and acetaminophen on performance during a 4-km cycling time-trial (4 T T). Eleven men, completed a 4 T T one h...
Source: PharmaNutrition - Category: Nutrition Source Type: research
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