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From Bahrain to Boston for very early onset IBD care

During a recent visit to Boston Children’s Hospital, three-year-old Gassen Boabed quietly entered the waiting room of the hospital’s Inflammatory Bowel Disease Center. With Mom and big brother in tow, the tiny toddler, boasting a pretty pink headband and nail polish to match, sat at a child-sized table, picked up crayons and started coloring. She was at ease, and her surroundings were familiar. For the past year and a half, Gassen, a native of Bahrain, a small island country east of Saudi Arabia, has been receiving treatment at Boston Children’s for a rare and debilitating condition called very early onset (VEO) inflammatory bowel disease (IBD).  The condition, which affects infants and children under 5, causes severe abdominal pain and bloody diarrhea, and it slows growth. The cause(s) of VEO-IBD remain unknown but likely include a combination of genetic and environmental factors. “Boston Children’s has been taking very good care of Gassen and us as well,” says Gassen’s mother Manal, with the assistance of an interpreter from the hospital’s Interpreter Services Department. “The way they have been dealing with her case has been excellent.” Gassen shows symptoms of VEO-IBD Soon after Gassen was born, her parents knew something was wrong. Their tiny baby girl wasn’t thriving. She had little-to-no appetite, was slow to gain weight and had painful bowel movements and diarrhea. “I exp...
Source: Thrive, Children's Hospital Boston - Category: Pediatrics Authors: Tags: Diseases & conditions Our patients’ stories Stem cell Athos Bousvaros Center for Inflammatory Bowel Disease (IBD) International Scott Snapper Source Type: news

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Source: Behavioural Pharmacology - Category: Drugs & Pharmacology Tags: Review Articles Source Type: research
In this study, we aimed to explore the potential role of miR-146a-5p (the mature form of miR-146a) in a mouse model of colitis induced by intracolonic injection of trinitrobenzene sulfonic acid (TNBS). We found that induction of colitis resulted in visceral hyperalgesia manifested by a decreased pain threshold to colorectal distension and upregulation of miR-146a-5p expression in the lumbosacral spinal cord. In situ hybridization and immunohistochemistry results showed that miR-146a-5p was colocalized with neuronal marker NeuN, but not with astrocytic marker GFAP or microglial marker IBA-1. Dual-luciferase reporter assay s...
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research
Conclusion Screening criteria for IBD in patients with SpA, and vice versa, have been developed. These criteria will be useful for early detection of both diseases.
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research
In this study, we estimated the prevalence of IBP and the subtypes of SpA in a tertiary hospital in Bangladesh. MethodsThis 1 year cross‐sectional study was conducted among 240 CLBP patients in a rheumatology outpatient clinic. Assessment of Spondyloarthritis International Society classification criteria of IBP and predefined recognized classification criteria were followed to define different subtypes of SpA. Means and standard deviations were reported for continuous variables. Descriptive and bi‐variate analyses were accordingly performed. ResultsOf 240 CLBP patients, 60 (25%) had IBP and 180 (75%) had mechanical bac...
Source: APLAR Journal of Rheumatology - Category: Rheumatology Authors: Tags: Original Article Source Type: research
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Abstract Chronic abdominal and pelvic pain are common, debilitating clinical conditions experienced by millions of patients around the globe. The origin of such pain commonly arises from the intestine and bladder, which share common primary roles; the collection, storage and expulsion of waste. These visceral organs are located in close proximity to one another, and also share common innervation from spinal afferent pathways. Chronic abdominal pain, constipation or diarrhoea are primary symptoms for patients with Irritable Bowel Syndrome (IBS) or Inflammatory Bowel Disease (IBD). Chronic pelvic pain, urinary urgen...
Source: Am J Physiol Gastroi... - Category: Gastroenterology Authors: Tags: Am J Physiol Gastrointest Liver Physiol Source Type: research
CONCLUSIONS: Extensive care should be taken to avoid ulcerative intestinal hemorrhage to elderly patients receiving multiple doses of non-steroidal anti-inflammatory drug patch for multiple days. PMID: 29043859 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
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Source: Skinmed - Category: Dermatology Authors: Tags: Skinmed Source Type: research
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Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Undoctored Wheat Belly Lifestyle acid reflux anti-aging autoimmune blood sugar bowel flora cholesterol Dr. Davis energy Gliadin gluten gluten-free grain-free grains health healthcare Inflammation joint pain low-carb Source Type: blogs
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