Rescue in vitro maturation (IVM) of immature oocytes in stimulated cycles in women with low functional ovarian reserve (LFOR)

Abstract Rescue in vitro maturation (IVM) is currently not a routine procedure in association with in vitro fertilization (IVF). We compared in a prospectively cohort study of 10 patients with normal functional ovarian reserve (NFOR) and of 25 with low functional ovarian reserve (LFOR), defined by abnormally high FSH and/or abnormally low AMH levels), IVM dynamics of immature oocytes. Following controlled ovarian hyperstimulation in IVF cycles, only immature oocytes underwent rescue IVM (for up to 48 h). Oocyte maturation dynamics, fertilization rates, embryo development, and pregnancy rates were then compared between NFOR and LFOR patients. Though proportion of MI and GV oocytes reaching MII stages within 48 h and rate of maturation of MI oocytes did not differ, in women with LFOR significantly more GV oocytes reached MII stage within 24 h (30.4 vs. 66.9 %; P = 0.013), while fertilization rates and embryo generation numbers were similar between both groups. Rescue IVM, thus, produced 1.5 additional embryos for transfer in women with LFOR and 1.6 in patients with NFOR, a highly significant difference in relative improvement in available embryo numbers for LFOR (+60.0 %) and NFOR women (+16.5 %). Rescue IVM, thus, not only demonstrates different time dynamics between women with LFOR and NFOR but also disproportionate efficacy in improving available embryo numbers for transfer in favor of LFOR patients. 1/7 patients, who reached ...
Source: Endocrine - Category: Endocrinology Source Type: research

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ORGANOPHOSPHATES IN MECONIUM OF NEWBORN BABIES WHOSE MOTHERS RESIDED IN AGRICULTURAL AREAS OF THAILAND. Southeast Asian J Trop Med Public Health. 2020 Mar 02;51(1):77-87 Authors: Onchoi C, Kongtip P, Nankongnab N, Chantanakul S, Sujirarat D, Woskie S Abstract Organophosphates (OPs) are widely used for pest and weed control in many countries including Thailand. In addition to causing environmental pollution, OPs affect human health by overstimulating neurotoxicants, and OP exposure during pregnancy can lead to adverse health effects of mothers and their fetuses. Using gas chromatography-mass spectrometr...
Source: Southeast Asian Journal of Tropical Medicine and Public Health - Category: Tropical Medicine Tags: Southeast Asian J Trop Med Public Health Source Type: research
ConclusionsAlthough rare, gynecologists should consider endometriosis-induced hemoperitoneum with spontaneous abortion in the differential diagnosis in women of reproductive age presenting with a positive serum human chorionic gonadotropin test result and acute abdomen with intra-abdominal bleeding.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
The objective of this work was to study the epidemiological profile of female victims of psychological violence before and after birth in the Sédhiou region. METHOD: An observational, cross-sectional and analytical study was carried out from December 4, 2018 to April 4, 2019. The study population consisted of all the women received for postnatal consultation in one of the referral health structures in the Sédhiou region. Data were collected using a survey form and a questionnaire administered to the women having met the inclusion criteria. The data were entered using CS Pro software and subsequently ...
Source: Revue d Epidemiologie et de Sante Publique - Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research
CONCLUSIONS: PA performed in the third trimester of pregnancy was associated with a protection to preterm birth. Pregnant women should be counseled to engage in PA to lower the risk of premature delivery. PMID: 32947261 [PubMed - as supplied by publisher]
Source: Journal of Physical Activity and Health - Category: Sports Medicine Tags: J Phys Act Health Source Type: research
Authors: Khan S, Spiegelman D, Walsh F, Mazibuko S, Pasipamire M, Chai B, Reis R, Mlambo K, Delva W, Khumalo G, Zwane M, Fleming Y, Mafara E, Hettema A, Lejeune C, Chao A, Bärnighausen T, Okello V Abstract INTRODUCTION: The WHO recommends antiretroviral treatment (ART) for all HIV-positive patients regardless of CD4 count or disease stage, referred to as "Early Access to ART for All" (EAAA). The health systems effects of EAAA implementation are unknown. This trial was implemented in a government-managed public health system with the aim to examine the "real world" impact of EAAA on care ret...
Source: Journal of the International AIDS Society - Category: Infectious Diseases Tags: J Int AIDS Soc Source Type: research
Abstract Somatic cell nuclear transfer (SCNT) is a powerful technique, although challenging, to study reprograming into the totipotent state of differentiated nuclei in mammals. This procedure was initially applied in farm animals, then rodents, and more recently in primates. Nuclear transfer of embryonic stem cells is known to be more efficient, but many types of somatic cells have now been successfully reprogramed with this procedure. Moreover, SCNT reprograming is more effective on a per cell basis than induced Pluripotent Stem Cells (iPSC) and provides interesting clues regarding the underlying processes. In t...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Condition:   Healthy Interventions:   Biological: Ad26.ZEBOV;   Biological: MVA-BN-Filo Sponsors:   Janssen Vaccines & Prevention B.V.;   Center for Family Health Research (CFHR);   Coalition for Epidemic Preparedness Innovations (CEPI);   Emory University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
 Many infertile couples automatically assume that if they can't get pregnant on their own, they're going to require medical attention , and seek out a gynecologist for assistance.While this is true for many couples, there are also lots of others who can solve the problem for themselves in the bedroom using simple medical tools, especially when the problem is a mechanical one  of their being unable to deposit the semen in the vagina.Part of the of the problem is most doctors will not explain this simpler option to them , because treating patients is their only source of income, and they can't afford to give away t...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
 While it's reassuring to remember that in case your infertility is due to a medical problem, you can always go to a doctor to seek medical help , the fact still remains that going to a doctor is an expensive exercise.You need to pay the consultation fees; you need to pay for the medicines; you need to pay for the scans and the treatment; and you need to take time away from work and make excuses for being absent.Also, doctor ’s clinics can be scary and intimidating. They poke and prod you; force you to assume highly undignified positions; disregard your privacy; and every time you go, there is a new strange...
Source: Dr.Malpani's Blog - Category: Reproduction Medicine Source Type: blogs
Daniel Griffin provides a clinical report on COVID-19, superspreading potential of SARS-CoV-2 in Hong Kong, structure of virion glycoprotein of a commmon cold coronavirus reveals changes driven by prolonged circulation in humans, and listener email. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Brianne Barker Guest: Daniel Griffin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Increased risk for COVID-19 during pregnancy (MMWR) COVID-19 and community and close contact exposures (MMWR) COVID-19 cluster...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
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