Enhancement of chemotherapy by prevention of tumor cell repair

(INSERM (Institut national de la santé et de la recherche médicale)) The body naturally tries to repair lesions in the DNA of tumour cells, and thus reduces the efficacy of chemotherapy. Blocking the mechanisms for DNA repair would help to potentiate chemotherapy by reducing the resistance of cells to treatment. A team directed by Frédéric Coin, Inserm Research Director in Strasbourg, has discovered a new drug that inhibits repair: spironolactone, which seems likely to be used in the very short term as an adjuvant to chemotherapy.
Source: EurekAlert! - Biology - Category: Biology Source Type: news