Sickle Cell Disease vs. the California Stem Cell Agency: Disease-a-week Challenge #19
Imagine: inside the veins of an African-American child, red blood cells: round and soft, doing their job, keeping the person alive. What would happen if those cells hardened and changed shape, curving into the letter "C", like a wheat-cutting sickle? First, the capillaries would clog, in what Sickle Cell Disease (SCD) doctors call a "crisis". Excruciating agony, like broken glass in the veins, a crisis may last an hour or a day, and the pain is just the beginning. "By twenty years of age, about 15% of children with SCD suffer major strokes...by 40 years of age, almost half have central nervous system damage ... cognitive dysfunction (mental problems) ... damage to lungs and kidneys.... frequent hospitalizations... (and face the likelihood of) early death..." Why does this nightmare condition single out African-Americans? The carrier state for SCD may be a defense against malaria, common to sub-Saharan Africa, but the defense is worse than the disease. Poverty makes things worse: African-Americans are almost three times more likely than whites to be poor, and accordingly lack decent medical insurance: Without medical advice, SCD sufferers may not even know even the most basic care: like the vital importance of drinking lots of water to stay well-hydrated. The more water a person drinks, the less likely it is that their abnormal blood cells will clog the capillaries. "Another effective treatment is a medication called hydroxyurea, which reduc...
CONCLUSIONS: This study shows that IHC with the tested antiserum increases the sensitivity of the diagnosis and may be recommended for routine use in EMB analyses of cardiac transplant patients with Chagas disease.
Conclusions: Burning pain relief might predict long-term results for the therapeutic use of MCS in CPSP. The substantia gelatinosa may play an important role in the modulation of pain relief mediated by MCS.Stereotact Funct Neurosurg
Imogen Riddett, 22, from Windsor, is literally a life-saver after stem cells she donated helped stranger, Claire Daly, from Coventry, overcome leukaemia aged 30.
Publication date: Available online 20 August 2018Source: Parasitology InternationalAuthor(s): David Nderu, Francis Kimani, Kelvin Thiong'o, Maureen Akinyi, Evaline Karanja, Christian G. Meyer, Thirumalaisamy P. VelavanAbstractRapid diagnostic tests (RDT) are valuable tools that support prudent and timely use of antimalarial drugs, particularly if reliable microscopy is not available. However, the performance and reliability of these tests vary between and within geographical regions. The present study evaluated the performance of routine malaria RDT in Kenyan febrile patients in Busia County, Kenya. A cross sectional study...
The National Institutes of Health (NIH) is seeking public comment on a proposal to amend the NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules. The proposal is intended to “streamline the oversight of human gene transfer clinical research protocols or gene therapy research and reduce duplicative reporting requirements already captured within the existing regulatory framework.” The agency proposes removing the NIH protocol submission, review, and reporting requirements under the current guidelines and modifying the responsibilities of the Recombinant DNA Advisory Committee (RA...
Integrative medicine, bogus cancer treatment, antiaging, low T, and more -- what do you need to know about the proliferation of these clinics in medicine?Medscape Public Health
Conclusions: Due to the risk of associated complications, cesarean sections should be performed with caution, when their benefits outweigh the risks.
Conclusion: individuals presented with TMD show lower levels of pain threshold, sleep quality and anxiety, as compared to healthy subjects. These results do not depend on the type of disorder presented.RESUMO Objetivo: avaliar o limiar de dor, qualidade do sono e n íveis de ansiedade em iindivíduos com diferentes tipos de disfunções temporomandibulares. Métodos: estudo controlado, observacional transversal. Foi utilizado o Research Diagnostic Criteria e os voluntários foram divididos em três grupos: Grupo A-disfunção muscular (n=15), Grupo B-disfunç &atil...
HOW to sleep: Sleep better by having a good bedtime routine, watching your diet, or by avoiding back pain-causing mattresses. Exercise could also help you to fall asleep fast, but what is the best activity to do if you can ’t sleep?
A traumatic breast injury may occur for many reasons, including a fall or sports injury. Symptoms can include pain and bruising, depending on the severity of the injury. A traumatic breast injury cannot cause cancer. Treatment typically involves rest and precautions to prevent further injury. Learn more here.
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