Sickle Cell Disease vs. the California Stem Cell Agency: Disease-a-week Challenge #19

Imagine: inside the veins of an African-American child, red blood cells: round and soft, doing their job, keeping the person alive. What would happen if those cells hardened and changed shape, curving into the letter "C", like a wheat-cutting sickle? First, the capillaries would clog, in what Sickle Cell Disease (SCD) doctors call a "crisis". Excruciating agony, like broken glass in the veins, a crisis may last an hour or a day, and the pain is just the beginning. "By twenty years of age, about 15% of children with SCD suffer major 40 years of age, almost half have central nervous system damage ... cognitive dysfunction (mental problems) ... damage to lungs and kidneys.... frequent hospitalizations... (and face the likelihood of) early death..." Why does this nightmare condition single out African-Americans? The carrier state for SCD may be a defense against malaria, common to sub-Saharan Africa, but the defense is worse than the disease. Poverty makes things worse: African-Americans are almost three times more likely than whites to be poor, and accordingly lack decent medical insurance: Without medical advice, SCD sufferers may not even know even the most basic care: like the vital importance of drinking lots of water to stay well-hydrated. The more water a person drinks, the less likely it is that their abnormal blood cells will clog the capillaries. "Another effective treatment is a medication called hydroxyurea, which reduc...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Authors: Santambrogio E, Orsucci L Abstract Helicobacter pylori (H. pylori) is one of the most common worldwide infection, which can affect adults as children. The prevalence of this bacterium is variable in different countries, depending on various hygienic and socioeconomic conditions and living customs. The major damaged tissues of the infection are in the upper gastrointestinal tract, causing gastritis, gastric and duodenal ulcer and gastrointestinal malignancy. Nevertheless, other disorders are associated with this pathogen, including several hematological diseases, such as iron deficiency anemia, immune throm...
Source: Minerva Gastroenterologica e Dietologica - Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
Publication date: Available online 17 April 2019Source: The Journal of Molecular DiagnosticsAuthor(s): Emily B. Hollister, Numan Oezguen, Bruno P. Chumpitazi, Ruth Ann Luna, Erica M. Weidler, Michelle Rubio-Gonzales, Mahmoud Dahdouli, Julia L. Cope, Toni-Ann Mistretta, Sabeen Raza, Ginger A. Metcalf, Donna M. Muzny, Richard A. Gibbs, Joseph F. Petrosino, Margaret Heitkemper, Tor C. Savidge, Robert J. Shulman, James VersalovicAccurate diagnosis and stratification of children with irritable bowel syndrome (IBS) remain challenging. Given the central role of recurrent abdominal pain in IBS, we evaluated the relationships of pe...
Source: The Journal of Molecular Diagnostics - Category: Pathology Source Type: research
ConclusionMetallosis-associated osteolysis should be suspected in cases with radiologically evident polyethylene wear after knee replacement. Recognizing that revision arthroplasty is very technically demanding in such cases, surgeons should have a back-up with modular revision components and a ready access to reconstructive options at this revision setting.
Source: Journal of Clinical Orthopaedics and Trauma - Category: Orthopaedics Source Type: research
Conclusions: FMF rarely involves the posterior pole. Visual loss in FMF results from either posterior scleritis or posterior uveitis. A high degree of suspicion of posterior scleritis is warranted in female patients with known FMF presenting with cloudy serous macular detachment.Case Rep Ophthalmol 2019;10:134 –139
Source: Case Reports in Ophthalmology - Category: Opthalmology Source Type: research
Conclusion Pethidine in low doses and dipyrone presented equivalent analgesia during labor. Public Registry of Clinical TrialsRBR-4hsyy4.Resumo Objetivo Comparar doses baixas de petidina com dipirona na analgesia de parto. M étodos Em um estudo prospectivo randomizado realizado pela Universidade de Fortaleza, Ceará, Brasil, entre maio e dezembro de 2016, 200 parturientes a termo, com contrações uterinas muito dolorosas e apresentando dilatação do colo uterino ≥ 5 cm, foram selecionadas para receber dose única intravenosa de 0,25 mg/kg de petidina (n = 100) ou 25 mg/kg de ...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
We report a very interesting case of a 27-year-old woman complaining of pelvic pain, with a subsequent diagnosis of extragenital Müllerian adenosarcoma. This is the first case reported in the literature with a complete and wide imaging description. Even if rare, Müllerian adenosarcoma should be hypothesized in case of young female patients presenting with suspicious pelvic mass.Resumo O adenosarcoma M ülleriano é uma doença ginecológica muito rara, compreendendo 5% dos sarcomas uterinos. Localizações extragenitais são ainda mais raras. Relatamos um caso muito interes...
Source: Revista Brasileira de Ginecologia e Obstetricia - Category: OBGYN Source Type: research
Publication date: Available online 18 April 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Nupur Tamhane, Megan McDowell, Mariana Oliva, Jean Paul Tanner, Lauri Hochberg, Marisa Baker, Anthony N Imudia, Emad MikhailAbstractStudy ObjectiveTo compare the detection rate of adenomyosis when ultrasound is performed by a radiologist compared to a gynecologic expert sonologist.DesignA retrospective, single center study.SettingUniversity teaching hospitalPatientsAll women above 18 years of age with a positive histopathology diagnosis of adenomyosis obtained in a hysterectomy specimen from October 1, 2011 - October ...
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionMinimally invasive removal of sacrocolpopexy mesh can be standardized using this step by step approach.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
ConclusionMinimal preoperative factors are associated with nonresponse for women having surgery for endometriosis. The severity of pain experienced by women with endometriosis may be used to predict their response to surgery.
Source: Journal of Minimally Invasive Gynecology - Category: OBGYN Source Type: research
Eight babies with "bubble boy disease" have had it fixed by a gene therapy made from one of the immune system's worst enemies
Source: Health News: - Category: Consumer Health News Source Type: news
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