Former GSK execs get $3.2M for research on a possible diabetes drug

A small Research Triangle Park company seeking to find next-generation drugs, received two federal grants totaling $3.2 million, an amount that will nearly triple the total the company has raised to date. NovaTarg – owned and led by former GlaxoSmithKline executives – will use the money to continue research on potential drug candidates for polycystic kidney disease and type 2 diabetes during this coming year. Diabetes is a potentially huge market, with some analysts estimating that even just…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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Once-weekly dulaglutide is effective for glycemic control in patients with type 2 diabetes and moderate to severe kidney disease, while helping to slow renal function decline, new research shows.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Medscape Today News Source Type: news
Tandem's t:slim X2 Insulin Pump with Basal-IQ technology is the second integrated insulin delivery device with a'predictive low glucose suspend'feature.FDA Approvals
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Source Type: news
The US FDA approval of a hybrid closed-looped system for glucose measurement and insulin delivery in adults 14 years and older last fall has now been extended to children as young as 7 years.FDA Approvals
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Diabetes & Endocrinology News Alert Source Type: news
A Yale study found that one in four patients admitted to cutting back on insulin use because of cost. The consequences can be deadly.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Diabetes Insulin Health Insurance and Managed Care Drugs (Pharmaceuticals) Prices (Fares, Fees and Rates) Generic Brands and Products Source Type: news
Stigma is associated with two - fold higher odds of poor glycemic control after adjustment for confounders
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Endocrinology, Family Medicine, Nursing, Pediatrics, Psychiatry, Journal, Source Type: news
Purpose: To investigate the relationship of the pre–anti-vascular endothelial growth factor (VEGF) retinal tissue area (RTA) and optical density (ODRT) of the retinal optical slice portion located in the central subfield, and their ratio (RTA/ODRT), in the presence of diabetic macular edema or of inraretinal cystic fluid in neovascular age-related macular degeneration, to central retinal thickness and best-corrected visual acuity after anti-VEGF treatment with ME resolution. Methods: The optical coherence tomography images and medical records of 33 patients (41 eyes) with neovascular age-related macular degenera...
Source: RETINA - Category: Opthalmology Tags: Original Study Source Type: research
Abstract Krüppel-like zinc finger proteins form one of the largest families of transcription factors. They function as key regulators of embryonic development and a wide range of other physiological processes, and are implicated in a variety of pathologies. GLI-similar 1-3 (GLIS1-3) constitute a subfamily of Krüppel-like zinc finger proteins that act either as activators or repressors of gene transcription. GLIS3 plays a critical role in the regulation of multiple biological processes and is a key regulator of pancreatic β cell generation and maturation, insulin gene expression, thyroid hormone bios...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research
Publication date: December 2016 Source:Kidney Research and Clinical Practice, Volume 35, Issue 4 Author(s): Yasuhiko Tomino Chronic kidney disease (CKD) is a worldwide public health problem that affects millions of people from all racial and ethnic groups. Although CKD is not one specific disease, it is a comprehensive syndrome that includes IgA nephropathy. As reported by the Japanese Society of Nephrology, 13.0 million people have CKD. In Japan, major causes of end-stage kidney disease are type 2 diabetic nephropathy, chronic glomerulonephritis, especially IgA nephropathy, hypertensive nephrosclerosis, and polycyst...
Source: Kidney Research and Clinical Practice - Category: Urology & Nephrology Source Type: research
Publication date: Available online 15 September 2016 Source:Kidney Research and Clinical Practice Author(s): Yasuhiko Tomino Chronic kidney disease (CKD) is a worldwide public health problem that affects millions of people from all racial and ethnic groups. Although CKD is not one specific disease, it is a comprehensive syndrome that includes IgA nephropathy. As reported by the Japanese Society of Nephrology, 13.0 million people have CKD. In Japan, major causes of end-stage kidney disease are type 2 diabetic nephropathy, chronic glomerulonephritis, especially IgA nephropathy, hypertensive nephrosclerosis, and polycys...
Source: Kidney Research and Clinical Practice - Category: Urology & Nephrology Source Type: research
  This randomized control trial of over 4000 high risk patients with Type 2 diabetes and eGFR> 30 ml/min, empagliflozin (a sodium-glucose cotransporter 2 inhibitor) when compared with placebo was associated with slower progression of kidney disease (12.7% vs 18.8% for worsening nephropathy and 1.5% vs 2.6% for doubling of serum creatinine) when added to the standard of care.  Renal replacement therapy was initiated in 0.3% of the treatment group vs 0.6% of the placebo group (55% lower relative risk).   : Intensive Diabetes Therapy and Glomerular Filtration Rate in Type 1 Diabetes...
Source: Nephrology Now - Category: Urology & Nephrology Authors: Tags: Chronic Kidney Disease Clinical Nephrology Clinical Trial Results Diabetes General Nephrology Source Type: research
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