Former GSK execs get $3.2M for research on a possible diabetes drug

A small Research Triangle Park company seeking to find next-generation drugs, received two federal grants totaling $3.2 million, an amount that will nearly triple the total the company has raised to date. NovaTarg – owned and led by former GlaxoSmithKline executives – will use the money to continue research on potential drug candidates for polycystic kidney disease and type 2 diabetes during this coming year. Diabetes is a potentially huge market, with some analysts estimating that even just…
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news

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In this study, we have systematically reviewed the relationships between KS and the cardiovascular system and the management of cardiovascular complication. In summary, patients with KS display increased cardiovascular risk profile, characterized by increased prevalence of metabolic alterations including dyslipidemia, diabetes mellitus (DM), and abnormalities in biomarkers of cardiovascular disease. KS subjects are characterized by subclinical abnormalities in endothelial function and in left ventricular (LV) systolic and diastolic function, which - when associated with chronotropic incompetence - may negatively influence ...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
Publication date: May 2019Source: Microchemical Journal, Volume 146Author(s): Chandra Shekhar Pundir, Mansi Malik, Reeti ChaudharyAbstractPyruvate (carboxylate anion of pyruvic acid) is an organic molecule, with a backbone of 3‑carbon atoms. Pyruvate is known to undergo several fates depending upon the organism under consideration. It is one of the only molecules involved in both synthesis and breakdown pathways, thereby making it a very busy molecule. Aberrant levels of this metabolite are known to cause several disorders like diabetes, cirrhosis, cardiovascular diseases and severe brain abnormalities. This is an attrac...
Source: Microchemical Journal - Category: Chemistry Source Type: research
Conclusions24 weeks of aldosterone antagonism reduced systolic blood pressure without changing vascular function in patients with early-stage ADPKD.FundingNIDDK, NIH National Center for Advancing Translational Sciences, and the Zell Family Foundation.Trial RegistrationRegistered at ClinicalTrials.gov with study number NCT01853553.
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
The objective of this study was to evaluate machine-learning algorithms for accurately predicting short-term outcomes after ORIF for ankle fractures. The Nationwide Inpatient Sample and Nationwide Readmissions Database were queried for adult patients ≥18 years old who underwent ORIF of an ankle fracture during 2013 or 2014. Morbidity and mortality, length of stay>3 days, and 30-day all-cause readmission were the outcomes of interest. Two machine-learning models were created to identify patient and hospital characteristics associated with the 3 outcomes. The machine learning models were evaluated using confusion matri...
Source: The Journal of Foot and Ankle Surgery - Category: Orthopaedics Source Type: research
A 60-year-old multi-morbid male patient with polycystic kidney disease and secondary chronic renal insufficiency stage G5 A3 according to Kidney Disease: Improving Global Outcomes (KDIGO) classification was referred to our hospital with radiological differential diagnoses of sarcoidosis, ectasia of the pulmonary arteries, lymphoma, or central bronchial carcinoma with contralateral hilar lymph node metastases. He had concomitant arterial hypertension, manifest osteoporosis due to renal osteopathy, secondary compensated renal hyperparathyroidism, compensated metabolic renal acidosis, and diabetes mellitus type 2.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: Image Source Type: research
Victorine B Nzana, Anusha Rohit, Deepu George, Madhusudan Vijayan, Milly Mathew, Sundar Sankaran, Palaniappan Nagarajan, Georgi AbrahamIndian Journal of Medical Microbiology 2018 36(2):282-284A 51-year-old female, with non-alcoholic liver cirrhosis, portal hypertension, type 2 diabetes mellitus, autosomal dominant polycystic kidney disease with a clipped cerebral aneurysm and chronic kidney disease stage 5 was on continuous ambulatory peritoneal dialysis (CAPD) for 6.5 years elsewhere. She came for opinion on continuation of CAPD as she had 21 episodes of peritonitis in 76 months. Her blood pressure was 80/50 mmHg. She was...
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research
Abstract Krüppel-like zinc finger proteins form one of the largest families of transcription factors. They function as key regulators of embryonic development and a wide range of other physiological processes, and are implicated in a variety of pathologies. GLI-similar 1-3 (GLIS1-3) constitute a subfamily of Krüppel-like zinc finger proteins that act either as activators or repressors of gene transcription. GLIS3 plays a critical role in the regulation of multiple biological processes and is a key regulator of pancreatic β cell generation and maturation, insulin gene expression, thyroid hormone bios...
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research
Publication date: December 2016 Source:Kidney Research and Clinical Practice, Volume 35, Issue 4 Author(s): Yasuhiko Tomino Chronic kidney disease (CKD) is a worldwide public health problem that affects millions of people from all racial and ethnic groups. Although CKD is not one specific disease, it is a comprehensive syndrome that includes IgA nephropathy. As reported by the Japanese Society of Nephrology, 13.0 million people have CKD. In Japan, major causes of end-stage kidney disease are type 2 diabetic nephropathy, chronic glomerulonephritis, especially IgA nephropathy, hypertensive nephrosclerosis, and polycyst...
Source: Kidney Research and Clinical Practice - Category: Urology & Nephrology Source Type: research
Publication date: Available online 15 September 2016 Source:Kidney Research and Clinical Practice Author(s): Yasuhiko Tomino Chronic kidney disease (CKD) is a worldwide public health problem that affects millions of people from all racial and ethnic groups. Although CKD is not one specific disease, it is a comprehensive syndrome that includes IgA nephropathy. As reported by the Japanese Society of Nephrology, 13.0 million people have CKD. In Japan, major causes of end-stage kidney disease are type 2 diabetic nephropathy, chronic glomerulonephritis, especially IgA nephropathy, hypertensive nephrosclerosis, and polycys...
Source: Kidney Research and Clinical Practice - Category: Urology & Nephrology Source Type: research
  This randomized control trial of over 4000 high risk patients with Type 2 diabetes and eGFR> 30 ml/min, empagliflozin (a sodium-glucose cotransporter 2 inhibitor) when compared with placebo was associated with slower progression of kidney disease (12.7% vs 18.8% for worsening nephropathy and 1.5% vs 2.6% for doubling of serum creatinine) when added to the standard of care.  Renal replacement therapy was initiated in 0.3% of the treatment group vs 0.6% of the placebo group (55% lower relative risk).   : Intensive Diabetes Therapy and Glomerular Filtration Rate in Type 1 Diabetes...
Source: Nephrology Now - Category: Urology & Nephrology Authors: Tags: Chronic Kidney Disease Clinical Nephrology Clinical Trial Results Diabetes General Nephrology Source Type: research
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