Predictors of Hypomania During Ventral Capsule/Ventral Striatum Deep Brain Stimulation.

Predictors of Hypomania During Ventral Capsule/Ventral Striatum Deep Brain Stimulation. J Neuropsychiatry Clin Neurosci. 2015 Sep 25;:appineuropsych15040089 Authors: Widge AS, Licon E, Zorowitz S, Corse A, Arulpragasam AR, Camprodon JA, Cusin C, Eskandar EN, Deckersbach T, Dougherty DD Abstract Deep brain stimulation (DBS) of the ventral capsule/ventral striatum (VC/VS) is a novel therapy for neuropsychiatric disorders. Hypomania is a known complication of VC/VS DBS, but who is at risk is less understood. Factors such as family history, combined with details of DBS programming, might quantify that risk. The authors performed an iterative modeling procedure on a VC/VS DBS patient registry to identify key predictors. Hypomania was less common for men and for patients stimulated on the ventral right contact. It was more common with right monopolar stimulation. These findings may help to establish decision rules to reduce complications of VC/VS DBS. PMID: 26404172 [PubMed - as supplied by publisher]
Source: Journal of Neuropsychiatry and Clinical Neurosciences - Category: Psychiatry Tags: J Neuropsychiatry Clin Neurosci Source Type: research