Two drugs proven more effective than standard kidney cancer treatment

Marilyn MalaraAUSTIN, Texas, Sept. 26 (UPI) -- A pair of drugs have overshadowed the success rate of standard kidney cancer therapies after new clinical trials proves they prolong survival.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news

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Publication date: February 2019Source: Biomedical Signal Processing and Control, Volume 48Author(s): Francisco F. Teles, João M. LemosAbstractDuring the last years several clinical decision support systems have been developed, some of which clearly improved the results obtained with standard clinical practice. However, this kind of decision computing process has not been quite explored in cancer treatment. In this work a control system that designs an optimal therapy based on adaptive control methods, aiming to allow the eradication of a metastatic renal cell carcinoma as quickly and efficiently as possible, and wit...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
AbstractMore than 3000 clinical trials are evaluating the clinical activity of the PD-1 checkpoint inhibitors as monotherapies and in combinations with other cancer therapies [1]. The PD-1 checkpoint inhibitors are remarkable for their clinical activities in shrinking tumors across a wide range of tumor types, in causing durable responses, and in their tolerability. These attributes position them as favorable agents in clinical combinations. Historically, approaches to cancer therapy combinations focused on agents with orthogonal activities to avoid shared resistance mechanisms and shared toxicities. Although CTLA-4/PD-1 c...
Source: Seminars in Immunopathology - Category: Pathology Source Type: research
ConclusionsThis case series represents the first description of potential skeletal adverse effects related to immune checkpoint inhibitors. These findings are important for providers caring for patients who experience musculoskeletal symptoms and may merit additional evaluation.
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
Abstract The combination of biologically active compounds and nanomaterials in biomedicine field is growing rapidly and provided excellent forecasts for the progress of facile non-invasive approaches for the diagnosis of cancer therapy. In this present study, we demonstrated that as-prepared gallic acid (GA) coated reduced graphene oxide (rGO) combined with radiofrequency (RF) ablation has facilitated for the treatment of human renal epithelial cancer (A-489) cells without disturbing the renal proximal epithelial (HK-2) cells. The successful biofabrication of GA onto the rGO nanostructure has been elaborated with ...
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
CONCLUSIONS: P3H4 suppressed the development of renal carcinoma through upregulating miR-1a and miR-13a, which provides fundamental leads for the future anti-cancer therapy. PMID: 30178839 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Publication date: 1 December 2018Source: Materials Science and Engineering: C, Volume 93Author(s): Zhengyao Jiang, Hailong Jin, Shu Sun, Changqing Chen, Jie Zhang, Zefeng Guo, Xiaoyou LiuAbstractThe combination of biologically active compounds and nanomaterials in biomedicine field is growing rapidly and provided excellent forecasts for the progress of facile non-invasive approaches for the diagnosis of cancer therapy. In this present study, we demonstrated that as-prepared gallic acid (GA) coated reduced graphene oxide (rGO) combined with radiofrequency (RF) ablation has facilitated for the treatment of human renal epithe...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Cancer treatment has been transformed by the use of monoclonal antibodies (mAbs) that block immune inhibitory ligands CTLA-4 and PD-1, known as immune checkpoint inhibitors (CPIs). With these options for treatment of cancers that are resistant to conventional cancer therapies, the life expectancy of patients with melanoma, lung cancer, renal cell carcinoma, and other cancers, has shown significant improvement. However, according to the journal Diabetes, some patients experience adverse effects. One percent of patients treated with anti –PD-1 or –PD-L1 CPIs develop diabetes.08/22/2018
Source: Kidney Cancer Association - Category: Urology & Nephrology Source Type: news
In this study, the medicinal properties of betulin from B. platyphylla var. japonica useful for cancer management were investigated. LC/MS analysis revealed that betulin is a main chemical component of the EtOH extract of B. platyphylla var. japonica bark, and betulin was isolated from EtOH extract using an LC/MS-guided isolation method. Its structure was identified with 1H and 13C NMR spectroscopic data and LC/MS analysis and then compared to the previously reported spectroscopic and physical data. We first verified the cytotoxicity of betulin against three human lung adenocarcinoma cell lines, A549, H1264, and Calu-6, wi...
Source: Archives of Pharmacal Research - Category: Drugs & Pharmacology Authors: Tags: Arch Pharm Res Source Type: research
The advancements in cancer therapy have improved the clinical outcomes of cancer patients in recent decades. However, advanced cancer therapy is expensive and requires good health care systems. For kidney canc...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
Publication date: Available online 6 July 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Yifeng Xue, Guoxin Yu, Zhengfei Shan, Zhonglian LiAbstractCancer in human society is one of the most problematic health issue responsible for outnumbered deaths worldwide. The consumption of developed NPs in cancer diagnosis is a rapidly emerging field of bio-medical nanotechnology. Recent years, greener synthesized metal oxide hybrid nanoparticles have attracted great attention in cytotoxicity to different cancer therapy. Herein, we report that Duchesnea indica plant mediated green synthesis plant extract ...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
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