Prognostic significance of monosomal karyotype in adult patients with acute myeloid leukemia treated with risk-adapted protocols

Conclusion Our results indicated that the MK was associated with lower Complete Remission (CR) rate. HD-Ara-C follow by allo-HSCT could improve the prognosis of MK positive AML patients. Teaser The clinical association of MK status in AML patients and various of practice protocols has not been well reported. This study conducted outcome evaluation in 225 AML patients with MK positive/negative status in minimum two years following up periods. Results showed the distribution of MK positive increased with age and related to complete remission. Consolidated therapy could provide optimal outcome.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research