Structural and functional analysis of BB0689 from Borrelia burgdorferi, a member of the bacterial CAP superfamily

In this study, the bacterial CAP domain structure was analyzed and compared with the previously solved crystal structures of representative CAPs, and the function of BB0689 was examined. To determine the potential function of BB0689 and ascertain whether the functions that have been attributed to the CAP domain proteins are conserved, the binding of previously reported CAP domain interaction partners was analyzed, and the results suggested that BB0689 has a unique function that is yet to be discovered.
Source: Journal of Structural Biology - Category: Biology Source Type: research

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Conclusion: GSTP1 and CYPs expressions are increased in intracranial tumors. These results should be confirmed with larger series and different enzyme subtypes.
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research
We report for the first time an association between altered BA profile, genetic variants implicated in AD, and cognitive changes in disease using a large multicenter study. These findings warrant further investigation of gut dysbiosis and possible role of gut-liver-brain axis in the pathogenesis of AD.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
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Source: Endocrine - Category: Endocrinology Source Type: research
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Source: Endocrine - Category: Endocrinology Source Type: research
Conditions:   Glioblastoma;   Cancer of Brain;   Glioblastoma Multiforme;   Brain Tumor Interventions:   Device: Tumor Treating Fields;   Drug: Temozolomide;   Radiation: Radiation Therapy Sponsors:   Providence Health & Services;   Providence Health&Services Brain&Spine Institute;   University of California, San Francisco;   NovoCure Ltd. Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Conditions:   Joint Infection;   Infection of Hip Joint (Disorder);   Infection of Shoulder Joint;   Septic Arthritis Interventions:   Diagnostic Test: Synovial Alpha-defensin assay;   Diagnostic Test: Synovial Neutrophil elastase assay;   Diagnostic Test: Synovial lactate assay;   Diagnostic Test: Synovial C-reactive Protein (CRP);   Diagnostic Test: Synovial Staphylococcus spp antigen panel;   Diagnostic Test: Sy novial Candida spp antigen panel;   Diagnostic Test: Synovial Enterococ...
Source: - Category: Research Source Type: clinical trials
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Source: Food Bioscience - Category: Food Science Source Type: research
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Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
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