Structural and functional analysis of BB0689 from Borrelia burgdorferi, a member of the bacterial CAP superfamily

In this study, the bacterial CAP domain structure was analyzed and compared with the previously solved crystal structures of representative CAPs, and the function of BB0689 was examined. To determine the potential function of BB0689 and ascertain whether the functions that have been attributed to the CAP domain proteins are conserved, the binding of previously reported CAP domain interaction partners was analyzed, and the results suggested that BB0689 has a unique function that is yet to be discovered.
Source: Journal of Structural Biology - Category: Biology Source Type: research

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Contributors : Masashi Muramatsu ; Suguru Nakagawa ; Tsuyoshi Osawa ; Takashi MinamiSeries Type : Expression profiling by arrayOrganism : Mus musculusTo elucidate the molecular mechanisms behind corneal angiogenesis in Dscr-1-/- mice, we performed microarray analysis using intact corneas from B6, Dscr-1-/- mice, ApoE-/- mice, Dscr-1-/- and ApoE-/- double null mutant mice and sutured corneas from B6, Dscr-1-/- and Dscr-1 Tg mouse.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
Background. Metrics for evaluating low-quality kidneys have failed to predict outcomes or reduce the kidney refusal and discard rates. Kidneys from extended-criteria donors (ECDs) and kidneys with ≥85% kidney donor profile indexes (KDPIs) might have different sensitivities to the proinflammatory milieu generated by brain death. We aimed to identify gene expression profile differences in innate immunity pathways between low-quality and ideal kidneys. Methods. Preimplantation kidney biopsies from ECD (n = 41) and standard-criteria donor (n = 39) were evaluated for real-time quantitative polymerase chain reaction gene...
Source: Transplantation - Category: Transplant Surgery Tags: Original Basic Science—General Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
Statins are the only Class I ISHLT recommendation in heart transplantation (HT) as an established therapy to reduce cardiac allograft vasculopathy (CAV) and improve survival. However, the goal LDL is not known with no formal recommendation on targets. We assessed if LDL
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (553) Source Type: research
Primary graft dysfunction (PGD) is the main cause of mortality during the first month and the second one within the first year after lung transplant (LT) Statins, 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, have shown to have immunomodulatory and antiinflamatory effects unrelated to their cholesterol-lowering function. We hypothesized that recipient's preoperative statin therapy is associated with decreased incidence of PGD after LT.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (383) Source Type: research
This study aims to examine the efficacy of high-intensity statin therapy compared to low-intensity, moderate-intensity, or no statins at preventing cardiac allograft vasculopathy (CAV) and related outcomes of rejection and mortality after cardiac transplant in the setting of tacrolimus as primary calcineurin inhibitor.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (508) Source Type: research
In this study, we analyzed myocardial gene expression profiles in cardiac allografts after donor simvastatin treatment.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (192) Source Type: research
Left ventricular (LV) global longitudinal strain (GLS) is a robust marker of subclinical myocardial dysfunction. Previous studies showed that as small as 2% reduction in GLS predicted major adverse event in heart transplant (HT) recipients, including cardiac allograft vasculopathy (CAV). Although low intensity statin is commonly used after HT to reduce CAV, the incremental impact of statin intensity on myocardial function is unknown.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (616) Source Type: research
ConclusionsStatin initiators had a lower risk of any ALI outcome compared with non-users within 18  months regardless of HIV and/or HCV status.
Source: American Journal of Cardiovascular Drugs - Category: Cardiology Source Type: research
Publication date: Available online 30 March 2020Source: Academic RadiologyAuthor(s): Hongdan Zhang, Li Xu, Zhiping Zhong, Yupin Liu, Yu Long, Shuqin Zhou
Source: Academic Radiology - Category: Radiology Source Type: research
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