Structural and functional analysis of BB0689 from Borrelia burgdorferi, a member of the bacterial CAP superfamily
In this study, the bacterial CAP domain structure was analyzed and compared with the previously solved crystal structures of representative CAPs, and the function of BB0689 was examined. To determine the potential function of BB0689 and ascertain whether the functions that have been attributed to the CAP domain proteins are conserved, the binding of previously reported CAP domain interaction partners was analyzed, and the results suggested that BB0689 has a unique function that is yet to be discovered.
In conclusion, this study shows that cholesterol clefts are relatively common in BCC, and suggests that cholesterol crystal deposition could be associated with longer disease duration and microtrauma.
Abstract: Lyme disease is the most commonly reported vector-borne disease in the United States. After initial antibiotic treatment for patients with Lyme disease, ongoing symptoms that may persist have considerable long-term impact on healthcare costs. Posttreatment Lyme disease syndrome is characterized by a host of chronic symptoms that can leave patients physically and mentally disabled.
Conclusion: Amylase was the best performer with a Sigma metrics value of 19.93, while sodium had the least average sigma values of 2.23. Actions should be taken to improve method performance for these parameters with sigma below 3. PMID: 30022890 [PubMed - in process]
Authors: Harari E, Eisen A PMID: 30023119 [PubMed]
Publication date: Available online 20 July 2018Source: Ticks and Tick-borne DiseasesAuthor(s): Tammi L. Johnson, Christine B. Graham, Sarah E. Maes, Andrias Hojgaard, Amy Fleshman, Karen A. Boegler, Mark J. Delory, Kimetha S. Slater, Sandor E. Karpathy, Jenna K. Bjork, David F. Neitzel, Elizabeth K. Schiffman, Rebecca J. EisenAbstractIn the north-central United States, the blacklegged tick (Ixodes scapularis) is currently known to vector seven human pathogens. These include five bacteria (Borrelia burgdorferi sensu stricto, Borrelia mayonii, Borrelia miyamotoi, Anaplasma phagocytophilum, Ehrlichia muris eauclairensis), one...
This study sought to evaluate the levels of total serum cholesterol in the host following exposure to MAP. Blood samples were collected from both sheep and cattle prior to experimental challenge with MAP and at monthly intervals post-challenge. Total serum cholesterol levels in sheep challenged with MAP were significantly elevated at 9 weeks post-inoculation (wpi) in comparison to controls. When stratified based on disease outcome, there was no significant difference in serum cholesterol at the timepoints examined between MAP exposed sheep that were susceptible and those that were resistant to Johne’s disease. There ...
Contributors : Aurobind Vidyarthi ; Tapan Agnihotri ; Nargis Khan ; Manoj K Tewari ; Bishan D Radotra ; Javed N AgrewalaSeries Type : Expression profiling by arrayOrganism : Homo sapiensDifferential gene expression was assesed of genes related to tumor associated macrophages in human gliomas
Contributors : Longtao Wu ; Kirk Cahill ; Bakhtiar YaminiSeries Type : Expression profiling by arrayOrganism : Homo sapiensWe identify the atypical inhibitor- κB protein, Bcl3, as a novel biomarker in gliomas whose expression level predicts response to therapy. Bcl3 is found at 19q13 and its expression level in glioma is regulated by copy number alteration. Mechanistically, Bcl3 mediates mesenchymal differentiation and its presence promotes resistance to cytotoxic DNA damage.
Publication date: Available online 20 July 2018Source: American Journal of Kidney DiseasesAuthor(s): Daniel E. Weiner, Meyeon Park, Hocine Tighiouart, Alin A. Joseph, Myra A. Carpenter, Nitender Goyal, Andrew A. House, Chi-yuan Hsu, Joachim H. Ix, Paul F. Jacques, Clifton E. Kew, S. Joseph Kim, John W. Kusek, Todd E. Pesavento, Marc A. Pfeffer, Stephen R. Smith, Matthew R. Weir, Andrew S. Levey, Andrew G. BostomRationale &ObjectiveCardiovascular disease (CVD) is common and overall graft survival is suboptimal among kidney transplant recipients. Although albuminuria is a known risk factor for adverse outcomes among pers...
ConclusionCurrent study proposes an automatic method for segmentation between non-enhancing tumor and vasogenic edema in HGG patients, based on an SVM classifier which used an alternative ground truth to that of radiologist’s manual delineation of tumor. The proposed methodology can prove to be a useful tool for pre and post-operative evaluation of glioma patients.