Structural and functional analysis of BB0689 from Borrelia burgdorferi, a member of the bacterial CAP superfamily

In this study, the bacterial CAP domain structure was analyzed and compared with the previously solved crystal structures of representative CAPs, and the function of BB0689 was examined. To determine the potential function of BB0689 and ascertain whether the functions that have been attributed to the CAP domain proteins are conserved, the binding of previously reported CAP domain interaction partners was analyzed, and the results suggested that BB0689 has a unique function that is yet to be discovered.
Source: Journal of Structural Biology - Category: Biology Source Type: research

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Conclusion: GSTP1 and CYPs expressions are increased in intracranial tumors. These results should be confirmed with larger series and different enzyme subtypes.
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research
We report for the first time an association between altered BA profile, genetic variants implicated in AD, and cognitive changes in disease using a large multicenter study. These findings warrant further investigation of gut dysbiosis and possible role of gut-liver-brain axis in the pathogenesis of AD.
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
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Source: Endocrine - Category: Endocrinology Source Type: research
This study aims to extract and validate new modified Friedewald formulae for estimating LDLC according to triglyceride (TG) levels in Iranians.MethodsTotal cholesterol (TC), high-density lipoprotein cholesterol (HDLC), LDLC, and TG were measured in 5030 fasted subjects. The original FF was used for estimating LDLC. Data were divided into training and validation data sets. For extracting modified Friedewald formulae, linear regression was used with TG as independent and TC, HDLC, and directly measured LDLC (D-LDLC) as dependent variables, respectively. An overall modified formula was extracted for TG concentrations
Source: Endocrine - Category: Endocrinology Source Type: research
Conditions:   Glioblastoma;   Cancer of Brain;   Glioblastoma Multiforme;   Brain Tumor Interventions:   Device: Tumor Treating Fields;   Drug: Temozolomide;   Radiation: Radiation Therapy Sponsors:   Providence Health & Services;   Providence Health&Services Brain&Spine Institute;   University of California, San Francisco;   NovoCure Ltd. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Joint Infection;   Infection of Hip Joint (Disorder);   Infection of Shoulder Joint;   Septic Arthritis Interventions:   Diagnostic Test: Synovial Alpha-defensin assay;   Diagnostic Test: Synovial Neutrophil elastase assay;   Diagnostic Test: Synovial lactate assay;   Diagnostic Test: Synovial C-reactive Protein (CRP);   Diagnostic Test: Synovial Staphylococcus spp antigen panel;   Diagnostic Test: Sy novial Candida spp antigen panel;   Diagnostic Test: Synovial Enterococ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 15 October 2018Source: Food BioscienceAuthor(s): Tariq Ismail, Zeshan Ahmad, Piero Sestili, Majid Hussain, Kashif Akram, Amir Ismail, Saeed AkhtarAbstractThe hypoglycemic effect of different forms of camel milk, i.e., pasteurized (CM), powdered (PcM) and evaporated (EcM) in a rat model of chemically-induced diabetes was studied. Diabetes was induced by a single intraperitoneal injection of streptozotocin (65 mg/kg b.w.). Diabetic rats were supplemented with CM (ad lib), PcM (18.4 g/kg b.w.) and EcM (12.2 g/kg b.w.) for a period of 21 days. EcM feeding was found to normalize...
Source: Food Bioscience - Category: Food Science Source Type: research
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Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSION: Non-contiguous PF relapses of ST grade II and III gliomas are rare. A high-grade ST tumor that is concomitantly progressing appears to be a predictor of poor survival. Conversely, the tumor course may be indolent if the ST lesion is low-grade and non-progressive at the time of PF involvement. The possible mechanism(s) behind this tropism are also discussed. PMID: 30314742 [PubMed - as supplied by publisher]
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
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