Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors.
Regulation of the breast cancer stem cell phenotype by hypoxia-inducible factors.
Clin Sci (Lond). 2015 Dec 1;129(12):1037-1045
Authors: Semenza GL
Abstract
The small subpopulation of breast cancer cells that possess the capability for self-renewal and formation of secondary tumours that recapitulate the heterogeneity of the primary tumour are referred to as tumour-initiating cells or BCSCs (breast cancer stem cells). The hypoxic tumour microenvironment and chemotherapy actively induce the BCSC phenotype. HIFs (hypoxia-inducible factors) are required and molecular mechanisms by which they promote the BCSC phenotype have recently been delineated. HIF inhibitors block chemotherapy-induced enrichment of BCSCs, suggesting that their use may improve the response to chemotherapy and increase the survival of breast cancer patients.
PMID: 26405042 [PubMed - as supplied by publisher]
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Semenza GL Tags: Clin Sci (Lond) Source Type: research
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