Successful metabolic adaptations leading to the prevention of high fat diet-induced murine cardiac remodeling

Conclusions: We have identified changes in metabolic signaling in obese HFD fed MRL mice that confer resistance to diabetic cardiomyopathy. The changes include a reduction of cardiac pAMPK, Glut4 and hexokinase2 in the MRL HFD hearts. Overall the MRL hearts down regulate glucose metabolism and favor lipid metabolism. These adaptations are essential to pursue for the identification of novel therapeutic targets to combat obesity related cardiomyopathy.
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Source Type: research