Testosterone and estradiol treatments differently affect pituitary-thyroid axis and liver deiodinase 1 activity in orchidectomized middle-aged rats.

In conclusion, androgenization enhanced pituitary TSHβ RIF, thyroid activation and liver Dio1 enzyme activity in Orx-MA, without elevating serum TSH as in Orx-YA rats. Estrogenization induced pituitary enlargement with no effect on pituitary TSHβ RIF, serum TSH or liver Dio1 activity. E also induced alterations in thyroid histology that indicate mild suppression of its functioning, and contributed to thyroid blood vessel enlargement in Orx-MA rats. PMID: 26384168 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/26384168?dopt=Abstract

Source: Experimental Gerontology - September 14, 2015 Category: Geriatrics Authors: Šošić-Jurjević B, Filipović B, Renko K, Miler M, Trifunović S, Ajdžanovič V, Kӧhrle J, Milošević V Tags: Exp Gerontol Source Type: research