Side Effects and Complications of Proton Pump Inhibitors: A Pediatric Perspective

Proton pump inhibitors (PPIs) are a class of acid suppression medications that block gastric parietal cell acid production by irreversibly inhibiting the luminal H+/K+ adenylpyrophosphatase (ATPase).1 PPIs are used for a variety of conditions involving inflammation of the upper gastrointestinal tract in children, including gastroesophageal reflux disease, erosive esophagitis, gastric and duodenal ulcers, eosinophilic esophagitis, and Helicobacter pylori gastritis.2-4 Alternative uses for PPIs are increasing, and include treatment of various pediatric respiratory symptoms, sleep disorders, and even irritability or excessive crying in infants.
Source: The Journal of Pediatrics - Category: Pediatrics Authors: Tags: Medical Progress Source Type: research