Autologous stem cell transplantation (ASCT) in patients with POEMS syndrome results in durable symptomatic disease control: A retrospective study of the Plasma Cell Disorder sub-committee of the Chronic Malignancies Working Party of the EBMT

POEMS syndrome is a rare paraneoplastic syndrome associated with clonal plasma cells. ASCT is believed to be an effective treatment in the control of the disease. Patient-, disease-& transplant-related variables were collected from the EBMT database. Systemic involvement & response was detailed utilizing an organ response tool pre- & post-ASCT. 127 patients underwent an ASCT between 1997-2010. The median age was 49.9 years (range 26.3, 69 years). The median time from diagnosis to ASCT was 7.5 months (range 0.8, 346).

Source: Clinical Lymphoma, Myeloma and Leukemia - September 1, 2015 Category: Hematology Authors: G. Cook, S. Iacobelli, A. van Biezen, D. Ziagkos, V. LeBlond, D. Bordessoule, G. McQuaker, P. Dreger, A. Rambaldi, K. Halaburda, M. Rovira, G. Leone, J. Byrne, D. Caballero, A. Nagler, G. Ossenkoppele, M. Cook, N. Kroger, T. de Witte, T. Morris, L. Garder Source Type: research