Outcome of t(4;14) in Multiple Myeloma – Princess Margaret Cancer Centre Experience Over the Last 10 Years

Translocation (4;14) is identified by FISH cytogenetics in approximately 15% of myeloma patients (pts). Pts have a poor outcome with initial response to induction chemotherapy but followed by rapid relapse and resistance to alkylating agents. We reviewed outcomes of 74 consecutive myeloma pts with t(4;14) between October 2002 and July 2012. Our goal was to evaluate the impact of pts characteristics on OS and to assess outcome according to treatments received. Clinical characteristics are presented in Table 1.

Source: Clinical Lymphoma, Myeloma and Leukemia - September 1, 2015 Category: Hematology Authors: V. Kukreti, M. Maganti, D. Reece, E. Masih-Khan, V.H. Jimenez-Zepeda, S. Trudel, C. Chen, R. Tiedemann, S. Farooki Source Type: research