Expression of Cancer Testis Antigens (CTAs) in Plasmacytoma with and without Bone Marrow Involvement

CTAs such as MAGE, NY-ESO-1 and CT7 are expressed in various types of tumors and in normal adult tissues only in testicular germ cells. Based on their tumor-associated expression pattern, CTAs are regarded as ideal vaccine targets for cancer immunotherapy. CTAs are highly expressed in various solid cancers such as melanoma as well as certain types of carcinomas and sarcomas but show little presence in most hematological malignancies. In plasma cell myeloma (PCM), however, single CTAs are highly expressed and show correlation with disease progression.

Source: Clinical Lymphoma, Myeloma and Leukemia - September 1, 2015 Category: Hematology Authors: A. Jungbluth, D. Frosina, M. Fayad, J. Pichardo, G. Koehne, A. Dogan, A. Chiu Source Type: research