An ecological measure of immune-cancer colocalization as a prognostic factor for breast cancer
Conclusions:
Our study demonstrates how ecological methods applied to the tumor microenvironment using routine histology can provide reproducible, quantitative biomarkers for identifying high-risk breast cancer patients. We found that the clinical value of immune-cancer interaction patterns is highly subtype-specific but substantial and independent to known clinicopathologic variables that mostly focused on cancer itself. Our approach can be developed into computer-assisted prediction based on histology samples that are already routinely collected.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Carlo MaleyKonrad KoelbleRachael NatrajanAthena AktipisYinyin Yuan Source Type: research
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