Na(+) -Ca(2+) Exchanger, Leak K(+) Channel and Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel Comediate the Histamine-Induced Excitation on Rat Inferior Vestibular Nucleus Neurons.

CONCLUSION: These results demonstrate the multiple ionic mechanisms underlying the excitatory modulation of histamine/central histaminergic system on IVN neurons and the related vestibular reflexes and functions. The findings also suggest potential targets for the treatment of vestibular disorders in the clinic, at the level of ionic channels in central vestibular nuclei.
PMID: 26387685 [PubMed - as supplied by publisher]

Source: CNS Neuroscience and Therapeutics - September 21, 2015 Category: Neuroscience Authors: Yu L, Zhang XY, Cao SL, Peng SY, Ji DY, Zhu JN, Wang JJ Tags: CNS Neurosci Ther Source Type: research