The Sheep as a Model of Brain Injury in the Premature Infant

We describe a global cerebral ischemia preparation that replicates major features of acute and chronic human cerebral injury and which has provided access to complex clinically relevant studies of cerebral blood flow and neuro-imaging that are not feasible in smaller laboratory animals. Despite the higher costs and technical challenges of instrumented preterm fetal sheep models, they allow an integrated analysis of the spectrum of insults that appear to contribute to cerebral injury in human preterm infants.
Source: Springer protocols feed by Neuroscience - Category: Neuroscience Source Type: news