Perinatal Intracerebral Hemorrhage Model and Developmental Disability

Perinatal intracerebral hemorrhage, also known as germinal matrix hemorrhage (GMH), refers to the bleeding that arises from the sub-ependymal (or periventricular) germinal region of the immature brain. Intraventricular hemorrhage (IVH) refers to the bleeding that extends into the ventricles, usually as an extension of GMH. Clinical studies have shown that infants who experience GMH/IVH may develop hydrocephalus or suffer from long-term neurological dysfunctions, including cerebral palsy, seizures, and learning disabilities. Understanding the pathogenesis of subsequent brain damage is important for the prevention and management of GMH/IVH. Appropriate animal models are necessary to achieve this understanding. Rodent models of GMH/IVH are economical, homogenous within a strain, and suitable for studying some long-term outcomes. This chapter reviews rodent models of GMH/IVH and their neurobehavioral outcomes.
Source: Springer protocols feed by Neuroscience - Category: Neuroscience Source Type: news