Hidradenitis Suppurativa: A Review with a Focus on Treatment Data.
Hidradenitis Suppurativa: A Review with a Focus on Treatment Data. Skin Therapy Lett. 2015 Aug;20(4):1-8 Authors: Barlev D, Eisen DB, Alikhan A Abstract Hidradenitis suppurativa (HS) is a chronic disease of the follicular unit that often leads to marked impairment of quality of life and usually affects the axillary, perineum and inframammary regions resulting in tender subcutaneous nodules, abscesses, fibrosis and sinus tract formation. New updates on HS underscores the role of various genes as well as the innate and adaptive immune response in its pathogenesis. Although every patient requires an individualized approach to treatment, topical therapy and antibiotics are mainly used for mild to moderate disease, whereas various systemic immune modulators and/or surgical approaches play a pivotal role in moderate to severe disease. New treatments using various immune modulators, laser modalities and other novel agents provide clinicians with better ways of managing HS. PMID: 26382710 [PubMed - in process]
Abstract Hidradenitis suppurativa (HS) is an inflammatory skin condition affecting skin fold regions. HS is associated with a marked reduction in quality-of-life (QoL), financial burden,1 and high incidence of comorbid mental illness.2 This disease begins in early adulthood, a time of psychiatric vulnerability and immense professional growth. This is a critical time in planning careers and establishing social contacts that overtime may change an individual's life course.3 However, there is limited research on HS's impact on employment and work productivity. PMID: 31707731 [PubMed - as supplied by publisher]
DISCUSSION: The HiSQOL is a reliable and valid instrument to measure HS-specific HRQOL for clinical trials. PMID: 31705538 [PubMed - as supplied by publisher]
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease characterized by painful deep-seated recurrent nodules and abscesses in axillary, inguinal and perineal areas (Jemec, 2012). It is a complex disease with an aetiology including genetic variations, environmental factors and aberrant innate and adaptive immune functions (Alikhan et al., 2009, Kelly et al., 2014, Moran et al., 2017).
Abstract Hidradenitis suppurativa is a chronic folliculitis affecting intertriginous areas. Onset generally occurs in young adulthood to middle adulthood (18 to 39 years of age). Females and blacks are more than twice as likely to be affected. Additional risk factors include family history, smoking, and obesity. Hidradenitis suppurativa is associated with several comorbidities, including diabetes mellitus and Crohn disease. The clinical presentation of hidradenitis suppurativa ranges from rare, mild inflammatory nodules to widespread abscesses, sinus tracts, and scarring. Quality of life is often affected, and pat...
Is this modified approach based on the TIME concept useful in the topical management of hidradenitis suppurativa?Wounds
ConclusionsThis is the first quantitative analysis performed for the evaluation of muscle electrical activity after perforator flap surgery. Perforator pedicle intra-muscular dissection does not cause any injury to the muscle fibers. TDAP flap confirms to be a safe procedure for latissimus dorsi muscle function.Level of evidence: Level III, therapeutic study.
Condition: Hidradenitis Suppurativa Interventions: Other: Electronic Reporting; Drug: Adalimumab Sponsor: Wake Forest University Health Sciences Not yet recruiting